ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Skeletal muscle and organ masses differ in overweight adults with type 2 diabetes.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The Association between Body Composition using Dual energy X-ray Absorptiometry and Type-2 Diabetes: A Systematic Review and Meta-Analysis of Observational studies.Scientific reports · 2019Pooled it
- Changes in skeletal muscle and organ size after a weight-loss intervention in overweight and obese type 2 diabetic patients.The American journal of clinical nutrition · 2017Trial
- Defining Healthy Weight Loss and Target Weight in the Era of Highly Effective Treatment of Patients With Obesity.Journal of cachexia, sarcopenia and muscle · 2026Review
- Hepatic and abdominal adiposity in type 2 diabetes as assessed with machine learning on computed tomography scans.Diabetes, obesity & metabolism · 2026Article
- Understanding the Increasing Prevalence of Obesity in Patients With Type 1 Diabetes: Strategies for Improving Clinical Care.Obesity (Silver Spring, Md.) · 2025Review
- Skeletal Muscle, Skin, and Bone as Three Major Nitrate Reservoirs in Mammals: Chemiluminescence andNutrients · 2024Article
- Spleen volume is independently associated with non-alcoholic fatty liver disease, liver volume and liver fibrosis.Heliyon · 2024Article
- The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness.Frontiers in physiology · 2023Review
- Association of abdominal muscle area and density with glucose regulation: The multi-ethnic study of atherosclerosis (MESA).Diabetes/metabolism research and reviews · 2022Article
- Are body surface area based estimates of liver volume applicable to children with overweight or obesity? An in vivo validation study.Clinical and translational science · 2021Article
- The protective effect of hydrogen-rich water on rats with type 2 diabetes mellitus.Molecular and cellular biochemistry · 2021Article
- Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance.Contemporary clinical trials communications · 2020Article
- Association of Dietary Variety Status and Sarcopenia in Korean Elderly.Journal of bone metabolism · 2020Article
- Magnetic resonance imaging based modeling of microvascular perfusion in patients with peripheral artery disease.Journal of biomechanics · 2019Article
- Reliability and validity of the new VikingSlice software for computed tomography body composition analysis.European journal of clinical nutrition · 2019Article
- Fat-free mass is not lower 24 months postbariatric surgery than nonoperated matched controls.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2017Article
- Evaluation of Body Weight, Body Condition, and Muscle Condition in Cats with Hyperthyroidism.Journal of veterinary internal medicine · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Whether lean body mass (LBM) composition, especially skeletal muscle and abdominal organs, differs in adults with type 2 diabetes (T2DM) compared with nondiabetic healthy controls has not been investigated. A subset of African-American and Caucasian participants with T2DM from the Look AHEAD (Action for Health in Diabetes) trial had body composition assessed and compared with a sample of healthy controls. Skeletal muscle mass (SMM), liver, kidneys, and spleen mass were quantified using a contiguous slice magnetic resonance imaging (MRI) protocol. Cardiac mass was quantified by either a cardiac gated MRI protocol or by echocardiography. MRI volumes were converted to mass using assumed densities. Dual-energy X-ray absorptiometry assessed LBM. Using general linear models adjusted for height, weight, sex, age, race, and interactions of diabetes status with race or sex, persons with T2DM (n = 95) had less LBM (49.7 vs. 51.6 kg) and SMM (24.1 vs. 25.4 kg) and larger kidneys (0.40 vs. 0.36 kg) than controls (n = 76) (all P < 0.01). Caucasians with T2DM had larger livers (1.90 vs. 1.60 kg, P < 0.0001) and spleens (0.29 vs. 0.22 kg, P < 0.01), and T2DM men had less cardiac mass than controls (0.25 vs. 0.30 kg, P < 0.001). In this sample, T2DM is characterized by less relative skeletal muscle and cardiac mass in conjunction with larger kidneys, liver, and spleen. Further investigation is needed to establish the causes and metabolic consequences of these race- and sex-specific organ mass differences in T2DM.
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Registered trials
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