ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Exercise training and artery function in humans: nonresponse and its relationship to cardiovascular risk factors.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03355469 (Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Comparing Aerobic Interval Training with Other Forms of Physical Exercise for Brachial Artery Endothelial Function Improvement: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials.Sports medicine - open · 2025Pooled it
- Pooled it
- Effects of Different Intensities and Durations of Aerobic Exercise on Vascular Endothelial Function in Middle-Aged and Elderly People: A Meta-analysis.Frontiers in physiology · 2021Pooled it
- Meta-analysis of Exercise Training on Vascular Endothelial Function in Cancer Survivors.Integrative cancer therapies · 2018Pooled it
- Impact of resistance and endurance exercise training on femoral artery function: sex differences in humans.The Journal of physiology · 2025Trial
- Acute impact of inorganic nitrate supplementation after ischemia and during small muscle mass exercise in postmenopausal females: A pilot study.Physiological reports · 2024Trial
- Trial
- Endothelial function following interval exercise plus low-calorie diet treatment in obese females.Physiological reports · 2019Trial
- Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes.Journal of diabetes research · 2019Trial
- Trial
- Effects of Exercise on Flow-Mediated Dilation in Patients with Heart Failure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of cardiovascular development and disease · 2025Review
- Effects of aerobic training on brachial artery flow-mediated dilation in healthy adults: a meta-analysis of inter-individual response differences in randomized controlled trials.BMC sports science, medicine & rehabilitation · 2025Article
- Average and Interindividual Effects to a Comprehensive Cardiovascular Rehabilitation Program.International journal of environmental research and public health · 2022Article
- Impact of Exercise on Vascular Function in Middle-Aged and Older Adults: A Scoping Review.Sports (Basel, Switzerland) · 2022Article
- Sleep Deprivation Impairs Vascular Function in Healthy Women: A Clinical Trial.Annals of the American Thoracic Society · 2022Article
- VascuFit: vascular effects of non-linear periodized exercise training in sedentary adults with elevated cardiovascular risk - protocol for a randomized controlled trial.BMC cardiovascular disorders · 2022Article
- Dynamic Resistance Exercise Alters Blood ApoA-I Levels, Inflammatory Markers, and Metabolic Syndrome Markers in Elderly Women.Healthcare (Basel, Switzerland) · 2022Article
- Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes From a Pilot Randomized Clinical Trial.Journal for vascular ultrasound : JVU · 2022Article
- The Influence of an Acute Bout of Aerobic Exercise on Vascular Endothelial Function in Moderate Stages of Chronic Kidney Disease.Life (Basel, Switzerland) · 2022Article
- Characterizing the interindividual postexercise hypotension response for two order groups of concurrent training in patients with morbid obesity.Frontiers in physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involving 182 subjects who underwent supervised, large-muscle group, endurance-type exercise training interventions with pre-/posttraining measures of flow-mediated dilation (FMD%) to assess artery function. All studies adopted an identical FMD protocol (5-min ischemia, distal cuff inflation), contemporary echo-Doppler methodology, and observer-independent automated analysis. Linear regression analysis was used to identify factors contributing to changes in FMD%. We found that cardiopulmonary fitness improved, and weight, body mass index (BMI), cholesterol, and mean arterial pressure (MAP) decreased after training, while FMD% increased in 76% of subjects (P < 0.001). Training-induced increase in FMD% was predicted by lower body weight (β = -0.212), lower baseline FMD% (β = -0.469), lower training frequency (β = -0.256), and longer training duration (β = 0.367) (combined: P < 0.001, r = 0.63). With the exception of a modest correlation with total cholesterol (r = -0.243, P < 0.01), changes in traditional cardiovascular risk factors were not significantly related to changes in FMD% (P > 0.05). In conclusion, we found that, while some subjects do not demonstrate increases following exercise training, improvement in FMD% is present in those with lower pretraining body weight and endothelial function. Moreover, exercise training-induced change in FMD% did not correlate with changes in traditional cardiovascular risk factors, indicating that some cardioprotective effects of exercise training are independent of improvement in risk factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.