ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
A micromechanical model for estimating alveolar wall strain in mechanically ventilated edematous lungs.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Biomechanical characterization of human lung bullae using uniaxial tensile tests and CT-derived geometry-specific finite element analysis.Frontiers in physiology · 2026Article
- First Stabilize and then Gradually Recruit: A Paradigm Shift in Protective Mechanical Ventilation for Acute Lung Injury.Journal of clinical medicine · 2023Review
- AnFrontiers in bioengineering and biotechnology · 2022Article
- A Physiologically Informed Strategy to Effectively Open, Stabilize, and Protect the Acutely Injured Lung.Frontiers in physiology · 2020Review
- Determination of rheology and surface tension of airway surface liquid: a review of clinical relevance and measurement techniques.Respiratory research · 2019Review
- Acute lung injury: how to stabilize a broken lung.Critical care (London, England) · 2018Article
- On modeling edematous alveolar mechanics.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
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3 authors at 1 institution in 1 country.
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Abstract
To elucidate the micromechanics of pulmonary edema has been a significant medical concern, which is beneficial to better guide ventilator settings in clinical practice. In this paper, we present an adjoining two-alveoli model to quantitatively estimate strain and stress of alveolar walls in mechanically ventilated edematous lungs. The model takes into account the geometry of the alveolus, the effect of surface tension, the length-tension properties of parenchyma tissue, and the change in thickness of the alveolar wall. On the one hand, our model supports experimental findings (Perlman CE, Lederer DJ, Bhattacharya J. Am J Respir Cell Mol Biol 44: 34-39, 2011) that the presence of a liquid-filled alveolus protrudes into the neighboring air-filled alveolus with the shared septal strain amounting to a maximum value of 1.374 (corresponding to the maximum stress of 5.12 kPa) even at functional residual capacity; on the other hand, it further shows that the pattern of alveolar expansion appears heterogeneous or homogeneous, strongly depending on differences in air-liquid interface tension on alveolar segments. The proposed model is a preliminary step toward picturing a global topographical distribution of stress and strain on the scale of the lung as a whole to prevent ventilator-induced lung injury.
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