ReviewAmerican journal of Alzheimer's disease and other dementias2015
Melatonin and melatonin agonist for delirium in the elderly patients.
Review in American journal of Alzheimer's disease and other dementias, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03013790 (Melatonin Use in the Intensive Care Elderly Population), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Melatonin Use in the Intensive Care Elderly Population
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Melatonin for sleep disorders and cognition in dementia: a meta-analysis of randomized controlled trials.American journal of Alzheimer's disease and other dementias · 2015Pooled it
- Postoperative delirium in orthopedic patients - identifying contributing factors and therapeutic strategies: A review.Medicine · 2025Review
- The Chronological Trigger: The Orchestra Between Homeobox Genes and the Circadian Clock During Development.Biology of the cell · 2025Review
- Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults.Clinical interventions in aging · 2023Review
- The relationship between anesthesia and melatonin: a review.Frontiers in pharmacology · 2023Review
- Using Machine Learning Algorithms to Predict High-Risk Factors for Postoperative Delirium in Elderly Patients.Clinical interventions in aging · 2023Article
- Risk factors, time to onset and recurrence of delirium in a mixed medical-surgical ICU population: A secondary analysis using Cox and CHAID decision tree modeling.EXCLI journal · 2022Article
- Incidence and Risk Factors of Delirium in the Intensive Care Unit: A Prospective Cohort.BioMed research international · 2021Article
- Article
- Melatonin and the Prevention and Management of Delirium: A Scoping Study.Frontiers in medicine · 2017Article
- Sleep-wake cycle disturbances in elderly acute general medical inpatients: Longitudinal relationship to delirium and dementia.Alzheimer's & dementia (Amsterdam, Netherlands) · 2017Article
- Delirium in the elderly: A systematic review of pharmacological and non-pharmacological treatments.Dementia & neuropsychologiaArticle
- Melatonin Supplementation May Improve the Outcome of Patients with Hemorrhagic Stroke in the Intensive Care Unit.Journal of research in pharmacy practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this review is to summarize the available data on the use of melatonin and melatonin agonist for the prevention and management of delirium in the elderly patients from randomized controlled trials (RCTs). A systematic search of 5 major databases PubMed, MEDLINE, PsychINFO, Embase, and Cochrane Library was conducted. This search yielded a total of 2 RCTs for melatonin. One study compared melatonin to midazolam, clonidine, and control groups for the prevention and management of delirium in individuals who were pre- and posthip post-hip arthroplasty. The other study compared melatonin to placebo for the prevention of delirium in older adults admitted to an inpatient internal medicine service. Data from these 2 studies indicate that melatonin may have some benefit in the prevention and management of delirium in older adults. However, there is no evidence that melatonin reduces the severity of delirium or has any effect on behaviors or functions in these individuals. Melatonin was well tolerated in these 2 studies. The search for a melatonin agonist for delirium in the elderly patients yielded 1 study of ramelteon. In this study, ramelteon was found to be beneficial in preventing delirium in medically ill individuals when compared to placebo. Ramelteon was well tolerated in this study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.