ArticleRetina (Philadelphia, Pa.)2014
Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.
Article in Retina (Philadelphia, Pa.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- Association between sunlight exposure and risk of age-related macular degeneration: a meta-analysis.BMC ophthalmology · 2018Pooled it
- The interplay between vitamin D3 and Nrf2 signaling: mechanistic insights and therapeutic potentials.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Plasma Vitamin D and Intermediate Age-Related Macular Degeneration: Insights from the Longitudinal ALIENOR Study.Ophthalmology science · 2026Article
- Association of serum 25-hydroxyvitamin D levels with age-related macular degeneration and its clinical correlates: a cross-sectional study.Frontiers in endocrinology · 2025Observational
- Serum 25-hydroxy vitamin D levels in age-related macular degeneration.International journal of retina and vitreous · 2022Article
- Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells.Antioxidants (Basel, Switzerland) · 2019Article
- Serum 25-Hydroxyvitamin D Concentrations and Incidence of Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study.Investigative ophthalmology & visual science · 2019Article
- The association between blood vitamins D and E with age-related macular degeneration: A pilot study.Interventional medicine & applied science · 2018Article
- Association between serum vitamin D deficiency and age-related macular degeneration in Koreans: Clinical case-control pilot study.Medicine · 2018Article
- Vitamin D and regulation of vascular cell function.American journal of physiology. Heart and circulatory physiology · 2018Review
- Vitamin D and Age-Related Macular Degeneration.Nutrients · 2017Review
- Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre-miR-21 and VEGF.British journal of pharmacology · 2017Article
- Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration.Scientific reports · 2017Article
- Vitamin D Status and Prevalent Early Age-Related Macular Degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study.The journal of nutrition, health & aging · 2017Article
- Association of neovascular age-related macular degeneration with month and season of birth in Italy.Aging · 2016Article
- Serum 25-hydroxyvitamin D level is associated with myopia in the Korea national health and nutrition examination survey.Medicine · 2016Article
- Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients.Nutrients · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo compare 25-hydroxyvitamin D (25OHD) levels in patients with neovascular age-related macular degeneration (NVAMD) with patients with nonneovascular age-related macular degeneration and control patients.
methodsMedical records of all patients diagnosed with age-related macular degeneration and tested for serum 25OHD level at a single medical center were reviewed. Control patients were selected from patients diagnosed with pseudophakia but without age-related macular degeneration. The lowest 25OHD level available for each patient was recorded.
resultsTwo hundred sixteen patients with nonneovascular age-related macular degeneration, 146 with NVAMD, and 100 non-age-related macular degeneration control patients were included. The levels of 25OHD (mean ± SD) were significantly lower in NVAMD patients (26.1 ± 14.4 ng/mL) versus nonneovascular age-related macular degeneration (31.5 ± 18.2 ng/mL, P = 0.003) and control (29.4 ± 10.1 ng/mL, P = 0.049) patients. The prevalence of vitamin D insufficiency (<30 ng/mL 25OHD), deficiency (<20 ng/mL), and severe deficiency (<10 ng/mL) were highest in the NVAMD group. The highest quintile of 25OHD was associated with a 0.35 (95% confidence interval, 0.18-0.68) odds ratio for NVAMD.
conclusionThis is the largest study to compare 25OHD levels in patients with the different clinical forms of age-related macular degeneration. Mean 25OHD levels were lower and vitamin D deficiency was more prevalent in NVAMD patients. These associations suggest that further research is necessary regarding vitamin D deficiency as a potentially modifiable risk factor for the development of NVAMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.