ArticleMolecular microbiology2014
Co-ordinated regulation of the extracytoplasmic stress factor, sigmaE, with other Escherichia coli sigma factors by (p)ppGpp and DksA may be achieved by specific regulation of individual holoenzymes.
Article in Molecular microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Transcriptional regulatory networks of the human gut symbiont Bacteroides thetaiotaomicron are uncovered using machine learning.Nucleic acids research · 2025Article
- NsrR Represses σInternational journal of molecular sciences · 2025Article
- Regulation of phosphate starvation-specific responses inMicrobiology (Reading, England) · 2023Review
- Diverse molecular mechanisms of transcription regulation by the bacterial alarmone ppGpp.Molecular microbiology · 2022Review
- Escherichia coli segments its controls on carbon-dependent gene expression into global and specific regulations.Microbial biotechnology · 2021Article
- Inducible intracellular membranes: molecular aspects and emerging applications.Microbial cell factories · 2020Review
- Interactions between DksA and Stress-Responsive Alternative Sigma Factors Control Inorganic Polyphosphate Accumulation in Escherichia coli.Journal of bacteriology · 2020Article
- Physiological effects of overexpressed sigma factors on fermentative stress response of Zymomonas mobilis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Transcriptional Responses to ppGpp and DksA.Annual review of microbiology · 2018Review
- Sponges and Predators in the Small RNA World.Microbiology spectrum · 2018Article
- Global Regulation by CsrA and Its RNA Antagonists.Microbiology spectrum · 2018Review
- Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.Molecular cell · 2018Article
- DksA and ppGpp Regulate the σJournal of bacteriology · 2018Article
- Circuitry Linking the Global Csr- and σJournal of bacteriology · 2017Article
- Appropriate Regulation of the σJournal of bacteriology · 2017Article
- Themes and variations in gene regulation by extracytoplasmic function (ECF) sigma factors.Current opinion in microbiology · 2017Review
- The dual role of DksA protein in the regulation of Escherichia coli pArgX promoter.Nucleic acids research · 2016Article
- Characterization of acetic acid-detoxifying Escherichia coli evolved under phosphate starvation conditions.Microbial cell factories · 2016Article
- pH dependence of the stress regulator DksA.PloS one · 2015Article
- Why do bacteria regulate public goods by quorum sensing?-How the shapes of cost and benefit functions determine the form of optimal regulation.Frontiers in microbiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The E. coli alternative sigma factor, σ(E) , transcribes genes required to maintain the cell envelope and is activated by conditions that destabilize the envelope. σ(E) is also activated during entry into stationary phase in the absence of envelope stress by the alarmone (p)ppGpp. (p)ppGpp controls a large regulatory network, reducing expression of σ(70) -dependent genes required for rapid growth and activating σ(70) -dependent and alternative sigma factor-dependent genes required for stress survival. The DksA protein often potentiates the effects of (p)ppGpp. Here we examine regulation of σ(E) by (p)ppGpp and DksA following starvation for nutrients. We find that (p)ppGpp is required for increased σ(E) activity under all conditions tested, but the requirement for DksA varies. DksA is required during amino acid starvation, but is dispensable during phosphate starvation. In contrast, regulation of σ(S) is (p)ppGpp- and DksA-dependent under all conditions tested, while negative regulation of σ(70) is DksA- but not (p)ppGpp-dependent during phosphate starvation, yet requires both factors during amino acid starvation. These findings suggest that the mechanism of transcriptional regulation by (p)ppGpp and/or DksA cannot yet be explained by a unifying model and is specific to individual promoters, individual holoenzymes, and specific starvation conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.