ArticlePloS one2014
Associations between single nucleotide polymorphisms in cellular viral receptors and attachment factor-related genes and humoral immunity to rubella vaccination.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses.Experimental gerontology · 2019Pooled it
- Gene Expression Factors Associated with Rubella-Specific Humoral Immunity After a Third MMR Vaccine Dose.Viruses · 2025Article
- Vaccinomics: A scoping review.Vaccine · 2023Article
- Transcriptional signatures associated with rubella virus-specific humoral immunity after a third dose of MMR vaccine in women of childbearing age.European journal of immunology · 2021Article
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- Personalized Human Papillomavirus Vaccination for Persistence of Immunity for Cervical Cancer Prevention: A Critical Review With Experts' Opinions.Frontiers in oncology · 2020Review
- Genetic association between CD96 locus and immunogenicity to anti-TNF therapy in Crohn's disease.The pharmacogenomics journal · 2019Article
- Factors That Influence the Immune Response to Vaccination.Clinical microbiology reviews · 2019Review
- Article
- Characterization of rubella-specific humoral immunity following two doses of MMR vaccine using proteome microarray technology.PloS one · 2017Article
- Impact of host genetic polymorphisms on vaccine induced antibody response.Human vaccines & immunotherapeutics · 2016Review
- Single nucleotide polymorphisms/haplotypes associated with multiple rubella-specific immune response outcomes post-MMR immunization in healthy children.Immunogenetics · 2015Article
- Review
- Searching for the human genetic factors standing in the way of universally effective vaccines.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Single-nucleotide polymorphism associations in common with immune responses to measles and rubella vaccines.Immunogenetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundViral attachment and cell entry host factors are important for viral replication, pathogenesis, and the generation and sustenance of immune responses after infection and/or vaccination, and are plausible genetic regulators of vaccine-induced immunity.
methodsUsing a tag-SNP approach in candidate gene study, we assessed the role of selected cell surface receptor genes, attachment factor-related genes, along with other immune genes in the genetic control of immune response variations after live rubella vaccination in two independent study cohorts.
resultsOur analysis revealed evidence for multiple associations between genetic variants in the PVR, PVRL2, CD209/DC-SIGN, RARB, MOG, IL6 and other immune function-related genes and rubella-specific neutralizing antibodies after vaccination (meta p-value <0.05).
conclusionOur results indicate that multiple SNPs from genes involved in cell adhesion, viral attachment, and viral entry, as well as others in genes involved in signaling and/or immune response regulation, play a role in modulating humoral immune responses following live rubella vaccination.
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Registered trials
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