ArticlePloS one2014
Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Enhancer switching in cell lineage priming is linked to eRNA, Brg1's AT-hook, and SWI/SNF recruitment.Molecular cell · 2024Article
- Nuclear architecture and the structural basis of mitotic memory.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Review
- Function and regulation of transcription factors during mitosis-to-G1 transition.Open biology · 2022Review
- Transcription Control of Liver Development.Cells · 2021Review
- Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.Scientific reports · 2021Article
- BETting on a Transcriptional Deficit as the Main Cause for Cornelia de Lange Syndrome.Frontiers in molecular biosciences · 2021Review
- The Drosophila MLR COMPASS complex is essential for programming cis-regulatory information and maintaining epigenetic memory during development.Nucleic acids research · 2020Article
- Identification of GA-Binding Protein Transcription Factor Alpha Subunit (GABPA) as a Novel Bookmarking Factor.International journal of molecular sciences · 2019Article
- A changing paradigm of transcriptional memory propagation through mitosis.Nature reviews. Molecular cell biology · 2019Review
- Mitotic Gene Bookmarking: An Epigenetic Program to Maintain Normal and Cancer Phenotypes.Molecular cancer research : MCR · 2018Review
- Nuclear organization mediates cancer-compromised genetic and epigenetic control.Advances in biological regulation · 2018Review
- Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.Scientific reports · 2017Article
- A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.Molecular and cellular biology · 2017Article
- Rubinstein-Taybi Syndrome and Epigenetic Alterations.Advances in experimental medicine and biology · 2017Review
- Insights into the Roles of Midazolam in Cancer Therapy.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth.Advances in experimental medicine and biology · 2017Review
- BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.The Journal of clinical investigation · 2016Article
- Mitotic bookmarking: maintaining post-mitotic reprogramming of transcription reactivation.Current molecular biology reports · 2016Article
- Multi-layered epigenetic mechanisms contribute to transcriptional memory in T lymphocytes.BMC immunology · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
A central hallmark of epigenetic inheritance is the parental transmission of changes in patterns of gene expression to progeny without modification of DNA sequence. Although, the trans-generational conveyance of this molecular memory has been traditionally linked to covalent modification of histone and/or DNA, recent studies suggest a role for proteins that persist or remain bound within chromatin to "bookmark" specific loci for enhanced or potentiated responses in daughter cells immediately following cell division. In this report we describe a role for p300 in enabling gene bookmarking by pre-initiation complexes (PICs) containing RNA polymerase II (pol II), Mediator and TBP. Once formed these complexes require p300 to enable reacquisition of protein complex assemblies, chromatin modifications and long range chromatin interactions that facilitate post-mitotic transmission of transcriptional memory of prior environmental stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.