ArticlePloS one2014
Isolate-dependent growth, virulence, and cell wall composition in the human pathogen Aspergillus fumigatus.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Comparison of Morphological, Virulence, and Antifungal Susceptibility Characteristics WithinInfection and drug resistance · 2025Article
- Chitin Biosynthesis inJournal of fungi (Basel, Switzerland) · 2023Review
- Neutrophil and Macrophage NADPH Oxidase 2 Differentially Control Responses to Inflammation and to Aspergillus fumigatus in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Article
- Assessing Differences between Clinical Isolates ofPathogens (Basel, Switzerland) · 2022Article
- Review
- The Inhibitory Effect of Validamycin A onInternational journal of microbiology · 2020Article
- Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish.Journal of cell science · 2019Article
- Fumagillin, a Mycotoxin ofToxins · 2019Review
- Fungi and Atopy.Clinical reviews in allergy & immunology · 2019Review
- Revealing the Virulence Potential of Clinical and EnvironmentalFrontiers in microbiology · 2019Article
- Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin andFrontiers in immunology · 2019Article
- Animal Models of Aspergillosis.Comparative medicine · 2018Review
- Caspofungin Increases Fungal Chitin and Eosinophil and γδ T Cell-Dependent Pathology in Invasive Aspergillosis.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches.Cytokine · 2016Review
- Alarmin(g) the innate immune system to invasive fungal infections.Current opinion in microbiology · 2016Review
- Insights on the virulence of swine respiratory tract mycoplasmas through genome-scale metabolic modeling.BMC genomics · 2016Article
- Co-recognition of β-glucan and chitin and programming of adaptive immunity to Aspergillus fumigatus.Frontiers in microbiology · 2015Article
- Eosinophils are recruited in response to chitin exposure and enhance Th2-mediated immune pathology in Aspergillus fumigatus infection.Infection and immunity · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ubiquitous fungal pathogen Aspergillus fumigatus is a mediator of allergic sensitization and invasive disease in susceptible individuals. The significant genetic and phenotypic variability between and among clinical and environmental isolates are important considerations in host-pathogen studies of A. fumigatus-mediated disease. We observed decreased radial growth, rate of germination, and ability to establish colony growth in a single environmental isolate of A. fumigatus, Af5517, when compared to other clinical and environmental isolates. Af5517 also exhibited increased hyphal diameter and cell wall β-glucan and chitin content, with chitin most significantly increased. Morbidity, mortality, lung fungal burden, and tissue pathology were decreased in neutropenic Af5517-infected mice when compared to the clinical isolate Af293. Our results support previous findings that suggest a correlation between in vitro growth rates and in vivo virulence, and we propose that changes in cell wall composition may contribute to this phenotype.
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