ArticleNeuron2014
Optimal control of transient dynamics in balanced networks supports generation of complex movements.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.
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155 citing papers in PubMed.
- Tuft Dendrite Spikes Are Accompanied by Selective Input From Distinct Functional Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Data-driven reduced modeling of neural dynamics.Nature communications · 2026Article
- Sparse component analysis: A method that uncovers separable computations within neural population activity.Neuron · 2026Article
- Tuft dendrite spikes are accompanied by selective input from distinct functional networks.bioRxiv : the preprint server for biology · 2026Article
- Artificial plateau neurons with in-situ spike-malleability for rhythmic quadrupedal locomotion.Nature communications · 2026Article
- Functional reorganization of motor cortex connectivity during learning.bioRxiv : the preprint server for biology · 2026Article
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Approaches to Exceptional Points in the Framework of Non-Hermitian Random Matrices.Entropy (Basel, Switzerland) · 2026Article
- Article
- Can we infer excitation-inhibition balance from the spectrum of population activity?Communications biology · 2025Article
- A Phenomenological Reappraisal of Dynamical Systems in Psychopathology.Psychopathology · 2025Review
- A neural manifold view of the brain.Nature neuroscience · 2025Review
- Basal ganglia: an amplifier for preparatory activity in motor control.Biological cybernetics · 2025Article
- Stable recurrent dynamics in heterogeneous neuromorphic computing systems using excitatory and inhibitory plasticity.Nature communications · 2025Article
- Unraveling the neural code: analysis of large-scale two-photon microscopy data.Microscopy (Oxford, England) · 2025Review
- High-dimensional neuronal activity from low-dimensional latent dynamics: a solvable model.bioRxiv : the preprint server for biology · 2025Article
- Optimization and variability can coexist.ArXiv · 2025Article
- Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex.Nature communications · 2025Article
- Article
- Augmenting flexibility: mutual inhibition between inhibitory neurons expands functional diversity.iScience · 2025Article
95 more citing papers are in PubMed but not listed here.
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3 authors.
Funding
Abstract
Populations of neurons in motor cortex engage in complex transient dynamics of large amplitude during the execution of limb movements. Traditional network models with stochastically assigned synapses cannot reproduce this behavior. Here we introduce a class of cortical architectures with strong and random excitatory recurrence that is stabilized by intricate, fine-tuned inhibition, optimized from a control theory perspective. Such networks transiently amplify specific activity states and can be used to reliably execute multidimensional movement patterns. Similar to the experimental observations, these transients must be preceded by a steady-state initialization phase from which the network relaxes back into the background state by way of complex internal dynamics. In our networks, excitation and inhibition are as tightly balanced as recently reported in experiments across several brain areas, suggesting inhibitory control of complex excitatory recurrence as a generic organizational principle in cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.