ArticleInternational journal of experimental pathology2014
Destruction of the hepatocyte junction by intercellular invasion of Leptospira causes jaundice in a hamster model of Weil's disease.
Article in International journal of experimental pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 66 citations in OpenAlex.
- Weil's disease: rapid recovery following corticosteroid treatment: a case report.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Hamster Model of Leptospira Infection.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Peromyscus spp. Deer Mice as Rodent Model of Acute Leptospirosis.Emerging infectious diseases · 2025Article
- TLR4 competence and mouse models of sublethal leptospirosis.PLoS neglected tropical diseases · 2025Article
- Severe Leptospirosis with Apyrexia and an Atypical Presentation: Rapid Progression to Multi-Organ Failure.European journal of case reports in internal medicine · 2025Article
- Atypical clinical debut associated with Jarisch Herxheimer reaction in an asplenic patient with leptospirosis: case report and review.BMC infectious diseases · 2024Review
- Clinical presentation of human leptospirosis in febrile patients: Urabá, Colombia.PLoS neglected tropical diseases · 2024Observational
- A Comparative Study of Human Leptospirosis between Mayotte and Reunion Islands Highlights Distinct Clinical and Microbial Features Arising from Distinct Inter-Island Bacterial Ecology.The American journal of tropical medicine and hygiene · 2024Article
- Article
- Exudative glomerulonephritis associated with acute leptospirosis in dogs.Veterinary pathology · 2024Article
- Non-purulent myositis caused by direct invasion of skeletal muscle tissue byInfection and immunity · 2024Article
- Machine learning-based motion tracking reveals an inverse correlation between adhesivity and surface motility of the leptospirosis spirochete.Nature communications · 2023Article
- Degradation of p0071 and p120-catenin during adherens junction disassembly byFrontiers in cellular and infection microbiology · 2023Article
- Weil's Disease-Immunopathogenesis, Multiple Organ Failure, and Potential Role of Gut Microbiota.Biomolecules · 2022Review
- Gut microbiota involved in leptospiral infections.The ISME journal · 2022Article
- Disassembly of the apical junctional complex during the transmigration of Leptospira interrogans across polarized renal proximal tubule epithelial cells.Cellular microbiology · 2021Article
- A multipronged approach for the detection of leptospirosis in captive sloth bears (Melursus ursinus) in Agra and Bannerghatta sloth bear rescue centers in India.The Journal of veterinary medical science · 2021Article
- Correlation between renal distribution of leptospires during the acute phase and chronic renal dysfunction in a hamster model of infection with Leptospira interrogans.PLoS neglected tropical diseases · 2021Article
- Article
- Spirochete Flagella and Motility.Biomolecules · 2020Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weil's disease, the most severe form of leptospirosis, is characterized by jaundice, haemorrhage and renal failure. The mechanisms of jaundice caused by pathogenic Leptospira remain unclear. We therefore aimed to elucidate the mechanisms by integrating histopathological changes with serum biochemical abnormalities during the development of jaundice in a hamster model of Weil's disease. In this work, we obtained three-dimensional images of infected hamster livers using scanning electron microscope together with freeze-cracking and cross-cutting methods for sample preparation. The images displayed the corkscrew-shaped bacteria, which infiltrated the Disse's space, migrated between hepatocytes, detached the intercellular junctions and disrupted the bile canaliculi. Destruction of bile canaliculi coincided with the elevation of conjugated bilirubin, aspartate transaminase and alkaline phosphatase levels in serum, whereas serum alanine transaminase and γ-glutamyl transpeptidase levels increased slightly, but not significantly. We also found in ex vivo experiments that pathogenic, but not non-pathogenic leptospires, tend to adhere to the perijunctional region of hepatocyte couplets isolated from hamsters and initiate invasion of the intercellular junction within 1 h after co-incubation. Our results suggest that pathogenic leptospires invade the intercellular junctions of host hepatocytes, and this invasion contributes in the disruption of the junction. Subsequently, bile leaks from bile canaliculi and jaundice occurs immediately. Our findings revealed not only a novel pathogenicity of leptospires, but also a novel mechanism of jaundice induced by bacterial infection.
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