ArticleIntegrative biology : quantitative biosciences from nano to macro2014
Wearable multi-channel microelectrode membranes for elucidating electrophysiological phenotypes of injured myocardium.
Article in Integrative biology : quantitative biosciences from nano to macro, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
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- Fetal Electrocardiogram Extraction from the Mother's Abdominal Signal Using the Ensemble Kalman Filter.Sensors (Basel, Switzerland) · 2022Article
- A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies.Biosensors & bioelectronics · 2022Article
- Mechanisms ofJournal of cardiovascular development and disease · 2021Review
- Continuous Electrocardiogram Monitoring in Zebrafish with Prolonged Mild Anesthesia.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2020Article
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- Phenotyping an adult zebrafish lamp2 cardiomyopathy model identifies mTOR inhibition as a candidate therapy.Journal of molecular and cellular cardiology · 2019Article
- Acquisition, Processing and Analysis of Electrocardiogram in Awake Zebrafish.IEEE sensors journal · 2019Article
- Real-Time Monitoring and Analysis of Zebrafish Electrocardiogram with Anomaly Detection.Sensors (Basel, Switzerland) · 2017Article
- Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation.Scientific reports · 2016Article
- Power Approaches for Implantable Medical Devices.Sensors (Basel, Switzerland) · 2015Review
- Flexible and waterproof micro-sensors to uncover zebrafish circadian rhythms: The next generation of cardiac monitoring for drug screening.Biosensors & bioelectronics · 2015Article
- Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration.IEEE reviews in biomedical engineering · 2015Review
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- Optically gated beating-heart imaging.Frontiers in physiology · 2014Review
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Corrections and comments
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Authors and funding
12 authors at 7 institutions in 1 country.
Funding
Abstract
Understanding the regenerative capacity of small vertebrate models has provided new insights into the plasticity of injured myocardium. Here, we demonstrate the application of flexible microelectrode arrays (MEAs) in elucidating electrophysiological phenotypes of zebrafish and neonatal mouse models of heart regeneration. The 4-electrode MEA membranes were designed to detect electrical signals in the aquatic environment. They were micro-fabricated to adhere to the non-planar body surface of zebrafish and neonatal mice. The acquired signals were processed to display an electrocardiogram (ECG) with high signal-to-noise-ratios, and were validated via the use of conventional micro-needle electrodes. The 4-channel MEA provided signal stability and spatial resolution, revealing the site-specific electrical injury currents such as ST-depression in response to ventricular cryo-injury. Thus, our polymer-based and wearable MEA membranes provided electrophysiological insights into long-term conduction phenotypes for small vertebral models of heart injury and regeneration with a translational implication for monitoring cardiac patients.
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Registered trials
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