ArticlePLoS neglected tropical diseases2014
Invariant NKT cell response to dengue virus infection in human.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Innate Lymphoid Cells Activation and Transcriptomic Changes in Response to Human Dengue Infection.Frontiers in immunology · 2021Trial
- NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics.The Journal of clinical investigation · 2024Article
- Severe dengue progression beyond enhancement.Nature immunology · 2023Article
- Dengue Fever Complicated with Hemophagocytic Lymphohistiocytosis: A Case Report of Resolution with Steroid-Sparing Supportive Care.Tropical medicine and infectious disease · 2023Article
- Review
- Early Activation of iNKT Cells Increased Survival Time of BALB/c Mice in a Murine Model of Melioidosis.Infection and immunity · 2022Article
- Single-cell temporal analysis of natural dengue infection reveals skin-homing lymphocyte expansion one day before defervescence.iScience · 2022Article
- Type I Natural Killer T Cells as Key Regulators of the Immune Response to Infectious Diseases.Clinical microbiology reviews · 2021Review
- Innate Immune Cytokine Profiling and Biomarker Identification for Outcome in Dengue Patients.Frontiers in immunology · 2021Article
- T-cells producing multiple combinations of IFNγ, TNF and IL10 are associated with mild forms of dengue infection.Immunology · 2020Observational
- Adaptive immune responses to primary and secondary dengue virus infections.Nature reviews. Immunology · 2019Review
- Mosquito saliva alone has profound effects on the human immune system.PLoS neglected tropical diseases · 2018Article
- Immune-mediated cytokine storm and its role in severe dengue.Seminars in immunopathology · 2017Review
- Dengue-associated hemophagocytic lymphohistiocytosis in an adult: A case report and literature review.Medicine · 2017Review
- West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells.Clinical and experimental immunology · 2016Article
- Expansion of highly activated invariant natural killer T cells with altered phenotype in acute dengue infection.Clinical and experimental immunology · 2016Article
- Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection.Frontiers in immunology · 2016Review
- The Response of CD1d-Restricted Invariant NKT Cells to Microbial Pathogens and Their Products.Frontiers in immunology · 2015Review
- iNKT Cells and Their Potential Lipid Ligands during Viral Infection.Frontiers in immunology · 2015Review
- Regulation of NKT Cell Localization in Homeostasis and Infection.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF). While adaptive immune responses were found to be detrimental in the dengue pathogenesis, the roles of earlier innate events remain largely uninvestigated. Invariant natural killer T (iNKT) cells represent innate-like T cells that could dictate subsequent adaptive response but their role in human dengue virus infection is not known. We hypothesized that iNKT cells play a role in human dengue infection.
methodsBlood samples from a well-characterized cohort of children with DF, DHF, in comparison to non-dengue febrile illness (OFI) and healthy controls at various time points were studied. iNKT cells activation were analyzed by the expression of CD69 by flow cytometry. Their cytokine production was then analyzed after α-GalCer stimulation. Further, the CD1d expression on monocytes, and CD69 expression on conventional T cells were measured.
resultsiNKT cells were activated during acute dengue infection. The level of iNKT cell activation associates with the disease severity. Furthermore, these iNKT cells had altered functional response to subsequent ex vivo stimulation with α-GalCer. Moreover, during acute dengue infection, monocytic CD1d expression was also upregulated and conventional T cells also became activated.
conclusioniNKT cells might play an early and critical role in the pathogenesis of severe dengue viral infection in human. Targeting iNKT cells and CD1d serve as a potential therapeutic strategy for severe dengue infection in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.