ArticleNutrition research and practice2014
The anti-inflammatory effect of Indonesian Areca catechu leaf extract in vitro and in vivo.
Article in Nutrition research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- Anti-Neuroinflammatory Potential of Areca Nut Extract and Its Bioactive Compounds in Anthracene-Induced BV-2 Microglial Cell Activation.Nutrients · 2024Article
- Anti-Neuroinflammatory Effects ofCurrent issues in molecular biology · 2024Article
- Potential metabolites of Arecaceae family for the natural anti-osteoarthritis medicine: A review.Heliyon · 2022Review
- Fast Gelation of Poly(ionic liquid)-Based Injectable Antibacterial Hydrogels.Gels (Basel, Switzerland) · 2022Article
- Structural characterization and protective effects of polysaccharide fromFood chemistry: X · 2021Article
- Antioxidant Properties and Diet-Related α-Glucosidase and Lipase Inhibitory Activities of Yogurt Supplemented with Safflower (Food science of animal resources · 2021Review
- Biological Activity and Pharmacological Application of Pectic Polysaccharides: A Review.Polymers · 2018Review
- Phytochemicals and antioxidant capacity of some tropical edible plants.Asian-Australasian journal of animal sciences · 2018Article
- Article
- Areca nut extract protects against ovariectomy-induced osteoporosis in mice.Experimental and therapeutic medicine · 2017Article
- The Anti-Inflammatory Activity of Toonaciliatin K against Adjuvant Arthritis.BioMed research international · 2017Article
- Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders.International neurourology journal · 2016Review
- Anti-inflammatory effects of Hwang-Heuk-San, a traditional Korean herbal formulation, on lipopolysaccharide-stimulated murine macrophages.BMC complementary and alternative medicine · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesOverproduction of nitric oxide (NO) by the inducible nitric oxide synthase (iNOS) enzyme can cause inflammation. Cyclooxygenase-2 (COX-2) is also involved in the inflammatory response through regulation of nuclear factor-kappa B (NF-κB). Areca catechu is one of the known fruit plants of the Palmaceae family. It has been used for a long time as a source of herbal medicine in Indonesia. In this study, we explored the effect of Indonesian Areca catechu leaf ethanol extract (ACE) in lipopolysaccharide (LPS)-induced inflammation and carrageenan-induced paw edema models. Recently, this natural extract has been in the spotlight because of its efficacy and limited or no toxic side effects. However, the mechanism underlying its anti-inflammatory effect remains to be elucidated. MATERIALS/
methodsWe measured NO production by using the Griess reagent, and determined the expression levels of inflammation-related proteins, such as iNOS, COX2, and NF-κB, by western blot. To confirm the effect of ACE in vivo, we used the carrageenan-induced paw edema model.
resultsCompared to untreated cells, LPS-stimulated RAW 264.7 cells treated with ACE showed reduced NO generation and reduced iNOS and COX-2 expression. We found that the acute inflammatory response was significantly reduced by ACE in the carrageenan-induced paw edema model.
conclusionTaken together, these results suggest that ACE can inhibit inflammation and modulate NO generation via downregulation of iNOS levels and NF-κB signaling in vitro and in vivo. ACE may have a potential medical benefit as an anti-inflammation agent.
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