ReviewWorld journal of cardiology2014
Management of hypertension in primary aldosteronism.
Review in World journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- 7th Brazilian Guideline of Arterial Hypertension: Chapter 12 - Secondary Arterial HypertensionArquivos brasileiros de cardiologia · 2016Guideline
- Fewer Pills, Lower Bills: Antihypertensive and Cost Outcomes of Adrenalectomy in Primary Aldosteronism.Annals of surgical oncology · 2026Article
- Diagnostic Challenges of Adrenal Venous Sampling for Primary Hyperaldosteronism in a Patient With Subclinical Cushing's Syndrome: A Case Report.Clinical case reports · 2025Article
- Risk factors for renal impairment in primary aldosteronism: a retrospective study.Frontiers in endocrinology · 2025Article
- Article
- End-Organ Damage in Hypertension: An Insight on a Differentiated Outpatient Consultation.Cureus · 2023Article
- The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images.Diagnostics (Basel, Switzerland) · 2022Article
- Systems Biology Analysis of Temporal Dynamics That Govern Endothelial Response to Cyclic Stretch.Biomolecules · 2022Review
- Cost-effectiveness of adrenal vein sampling- vs computed tomography-guided adrenalectomy for unilateral adrenaloma in primary aldosteronism.Journal of endocrinological investigation · 2022Article
- Article
- Hyperaldosteronism from a large adrenal adenoma in a patient with bilateral adrenal nodules.Clinical case reports · 2020Article
- NP-59 test for preoperative localization of primary hyperaldosteronism.Langenbeck's archives of surgery · 2017Article
- Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation to hypertension via impairing PGC-1α recovery.Scientific reports · 2016Article
- Risk factors for renal impairment revealed after unilateral adrenalectomy in patients with primary aldosteronism.Medicine · 2016Article
- An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis.Polish journal of radiology · 2015Article
- Endocrine hypertension: An overview on the current etiopathogenesis and management options.World journal of hypertensionArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension causes significant morbidity and mortality worldwide, owing to its deleterious effects on the cardiovascular and renal systems. Primary hyperaldosteronism (PA) is the most common cause of reversible hypertension, affecting 5%-18% of adults with hypertension. PA is estimated to result from bilateral adrenal hyperplasia in two-thirds of patients, and from unilateral aldosterone-secreting adenoma in approximately one-third. Suspected cases are initially screened by measurement of the plasma aldosterone-renin-ratio, and may be confirmed by additional noninvasive tests. Localization of aldostosterone hypersecretion is then determined by computed tomography imaging, and in selective cases with adrenal vein sampling. Solitary adenomas are managed by laparoscopic or robotic resection, while bilateral hyperplasia is treated with mineralocorticoid antagonists. Biochemical cure following adrenalectomy occurs in 99% of patients, and hemodynamic improvement is seen in over 90%, prompting a reduction in quantity of anti-hypertensive medications in most patients. End-organ damage secondary to hypertension and excess aldosterone is significantly improved by both surgical and medical treatment, as manifested by decreased left ventricular hypertrophy, arterial stiffness, and proteinuria, highlighting the importance of proper diagnosis and treatment of primary hyperaldosteronism. Although numerous independent predictors of resolution of hypertension after adrenalectomy for unilateral adenomas have been described, the Aldosteronoma Resolution Score is a validated multifactorial model convenient for use in daily clinical practice.
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