ArticleExperimental and therapeutic medicine2014
Analysis of differentially expressed genes in cold-exposed mice to investigate the potential causes of cold-induced hypertension.
Article in Experimental and therapeutic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes.Scientific reports · 2024Article
- Cardiovascular disorders and exposure to chemical pollutants.Journal of preventive medicine and hygiene · 2024Article
- Single-Cell Ribonucleic Acid Sequencing Clarifies Cold Tolerance Mechanisms in the Pacific White Shrimp (Frontiers in genetics · 2021Article
- Individual sensitivity of cold pressor, environmental meteorological factors associated with blood pressure and its fluctuation.International journal of biometeorology · 2020Article
- Burden of non-accidental mortality attributable to ambient temperatures: a time series study in a high plateau area of southwest China.BMJ open · 2019Article
- TRPM8 and RAAS-mediated hypertension is critical for cold-induced immunosuppression in mice.Oncotarget · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold exposure is considered to be an important contributing factor to the high morbidity of hypertension. In order to elucidate the cause and mechanism of cold-induced hypertension (CIH), gene expression analysis was performed on microarray data for two groups of cold-exposed mice (4°C for 1 week and 4°C for 5 weeks, three replicates per group) and their respective control groups maintained at 30°C. Analysis results indicated that the differentially expressed genes with the most significance were associated with adaptive thermogenesis, fatty acid metabolism and energy metabolism. The expected marked increase in metabolism during cold exposure caused tissue hypoxia. Genes involved in the hypoxia-inducible factor signaling pathway were activated. In addition, genes associated with oxidative stress were significantly upregulated, including superoxide dismutase 2 (
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