ReviewGenome medicine2014
Genomic insights into the overlap between psychiatric disorders: implications for research and clinical practice.
Review in Genome medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
108 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Diagnostic accuracy of miRNAs in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Genetic and phenotypic similarity across major psychiatric disorders: a systematic review and quantitative assessment.Translational psychiatry · 2024Pooled it
- Integrative analysis of genome-wide association studies identifies novel loci associated with neuropsychiatric disorders.Translational psychiatry · 2021Pooled it
- Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders.Human brain mapping · 2017Pooled it
- Investigating the associations between neurodevelopmental and psychiatric genetic liability and adverse social and functional outcomes across childhood, adolescence and young-adulthood.Molecular psychiatry · 2026Article
- Transdiagnostic alterations of intrinsic brain activity in major psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2026Article
- Cumulative environmental exposures adversely impact social behaviour and are associated with dysregulation of genes and proteins involved in epigenetic, ribosomal, and immune regulation in male mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Dimensional phenotype measurement in children with rare genetic conditions: new insights into the aetiology of neurodevelopmental and psychiatric disorders.Frontiers in psychiatry · 2026Article
- Genetic nurture effects in depressive and anxiety disorders and symptoms, and in related traits.Molecular psychiatry · 2025Article
- Schizophrenia.Nature reviews. Disease primers · 2025Review
- Low Stability and Specificity of Polygenic Risk Scores for Major Psychiatric Disorders Limit Their Clinical Utility.Biological psychiatry · 2025Article
- Uncovering the genetic underpinnings for different psychiatric disorder combinations.Psychological medicine · 2025Article
- Restricted economic activity due to health conditions and risk of depression: results from the Korean Longitudinal Study of Aging.Frontiers in public health · 2025Article
- Multimorbidity in Severe Mental Illness as Part of the Neurodevelopmental Continuum: Physical Health-Related Endophenotypes of Schizophrenia-A Narrative Review.Brain sciences · 2024Review
- Gut Microbiota and Clinical Manifestations in Thai Pediatric Patients with Attention-Deficit Hyperactivity Disorder.Journal of personalized medicine · 2024Article
- The structure of psychiatric comorbidity without selection and assortative mating.Translational psychiatry · 2024Article
- Neuropsychiatric disorders, chronotype and sleep: A narrative review of GWAS findings and the application of Mendelian randomization to investigate causal relationships.Genes, brain, and behavior · 2024Review
- Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes.Frontiers in pharmacology · 2024Review
- nArgBP2 together with GKAP and SHANK3 forms a dynamic layered structure.Frontiers in cellular neuroscience · 2024Article
- Job satisfaction and job tenure of people with mental health disorders: a UK Biobank cohort study.Scandinavian journal of public health · 2023Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder, attention-deficit/hyperactivity disorder and autism spectrum disorder are common and result in significant morbidity and mortality. Although currently classified into distinct disorder categories, they show clinical overlap and familial co-aggregation, and share genetic risk factors. Recent advances in psychiatric genomics have provided insight into the potential mechanisms underlying the overlap between these disorders, implicating genes involved in neurodevelopment, synaptic plasticity, learning and memory. Furthermore, evidence from copy number variant, exome sequencing and genome-wide association studies supports a gradient of neurodevelopmental psychopathology indexed by mutational load or mutational severity, and cognitive impairment. These findings have important implications for psychiatric research, highlighting the need for new approaches to stratifying patients for research. They also point the way for work aiming to advance our understanding of the pathways from genotype to clinical phenotype, which will be required in order to inform new classification systems and to develop novel therapeutic strategies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.