ArticleEvolutionary applications2014
Population-level effects of fitness costs associated with repressible female-lethal transgene insertions in two pest insects.
Article in Evolutionary applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Interfering with DNA repair pathways to enhance CRISPR-Cas9-mediated homology-directed repair in a chelicerate genetic model.iScience · 2026Article
- Understanding the genetics of sex determination in insects and its relevance to genetic pest management.Insect molecular biology · 2025Review
- Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.Nature communications · 2024Article
- New Insights into theJournal of agricultural and food chemistry · 2023Review
- Self-limiting fall armyworm: a new approach in development for sustainable crop protection and resistance management.BMC biotechnology · 2022Article
- The impact of transgenesis on mosquito fitness: A review.Frontiers in insect science · 2022Review
- New self-sexingFrontiers in bioengineering and biotechnology · 2022Article
- Population-level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus.Evolutionary applications · 2020Article
- Identification and characterization of a Masculinizer homologue in the diamondback moth, Plutella xylostella.Insect molecular biology · 2020Article
- Daisy-chain gene drives for the alteration of local populations.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Aseptic Rearing and Infection with Gut Bacteria Improve the Fitness of Transgenic Diamondback Moth,Insects · 2019Article
- Combining the high-dose/refuge strategy and self-limiting transgenic insects in resistance management-A test in experimental mesocosms.Evolutionary applications · 2018Article
- Genetics-based methods for agricultural insect pest management.Agricultural and forest entomology · 2018Review
- Maintaining Quality of Candidate Strains of Transgenic Mosquitoes for Studies in Containment Facilities in Disease Endemic Countries.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2018Article
- Resistance to genetic insect control: Modelling the effects of space.Journal of theoretical biology · 2017Article
- Towards the genetic control of invasive species.Biological invasions · 2017Article
- Article
- Evolutionary biology and genetic techniques for insect control.Evolutionary applications · 2016Review
- Pest control and resistance management through release of insects carrying a male-selecting transgene.BMC biology · 2015Article
- Development and evaluation of male-only strains of the Australian sheep blowfly, Lucilia cuprina.BMC genetics · 2014Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic control strategies offer great potential for the sustainable and effective control of insect pests. These strategies involve the field release of transgenic insects with the aim of introducing engineered alleles into wild populations, either permanently or transiently. Their efficacy can therefore be reduced if transgene-associated fitness costs reduce the relative performance of released insects. We describe a method of measuring the fitness costs associated with transgenes by analyzing their evolutionary trajectories when placed in competition with wild-type alleles in replicated cage populations. Using this method, we estimated lifetime fitness costs associated with two repressible female-lethal transgenes in the diamondback moth and olive fly as being acceptable for field suppression programs. Furthermore, using these estimates of genotype-level fitness costs, we were able to project longer-term evolutionary trajectories for the transgenes investigated. Results from these projections demonstrate that although transgene-associated fitness costs will ultimately cause these transgenes to become extinct, even when engineered lethality is repressed, they may persist for varying periods of time before doing so. This implies that tetracycline-mediated transgene field persistence in these strains is unlikely and suggests that realistic estimates of transgene-associated fitness costs may be useful in trialing 'uncoupled' gene drive system components in the field.
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