Evidence map›Paper›PMID 24944481›Full record

ArticleWorld journal of gastroenterology2014

Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis.

Shi-Yong Xin, Xiao-Shan Feng, Li-Qing Zhou, Jun-Jun Sun, Xiao-Le Gao, Guo-Liang Yao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  12. MicroRNA-218 inhibits the proliferation, migration, and invasion and promotes apoptosis of gastric cancer cells by targeting LASP1.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  13. Review
  14. Review
  15. Profiling cell-free and circulating miRNA: a clinical diagnostic tool for different cancers.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Review
  16. Review
  17. Combination of miRNA and RNA functions as potential biomarkers for gastric cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
    Article
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  20. Thermo-chemotherapy Induced miR-218 upregulation inhibits the invasion of gastric cancer via targeting Gli2 and E-cadherin.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shi-Yong XinShi-Yong Xin, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Xiao-Shan FengShi-Yong Xin, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Li-Qing ZhouShi-Yong Xin, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Jun-Jun SunShi-Yong Xin, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Xiao-Le GaoShi-Yong Xin, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
Guo-Liang YaoShi-Yong Xin, Department of Urology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the expression of microRNA-218 (miR-218) in serum from gastric cancer patients and its relationship with clinicopathological characteristics.

methodsA total of 68 patients with pathologically diagnosed gastric cancer and 56 healthy individuals were recruited to this study. The expression of miR-218 was detected in the serum of gastric cancer patients and healthy individuals by quantitative real-time polymerase chain reaction. The clinical data were collected and analyzed by statistical software.

resultsmiR-218 was reduced significantly in the serum of gastric cancer patients compared to healthy individuals (1.15 ± 0.08 vs 0.37 ± 0.023; P = 0.026). In the gastric cancer group, serum expression of miR-218 was lower in patients with metastasis and poorly differentiated cancer compared with non-metastatic and well-differentiated cancer (0.19 ± 0.011 vs 0.45 ± 0.021, P = 0.031 and 0.21 ± 0.019 vs 0.49 ± 0.021, P = 0.025). Serum miR-218 was found to be significantly associated with gastric cancer metastasis (P = 0.003), tumor T stage (P = 0.018) and tumor grade (P = 0.012). Low serum expression of miR-218 was related to an increase in the stage of gastric cancer. The expression level of miR-218 in the serum was correlated with the 3-year survival. Ninety-seven percent of patients with a high level of miR-218 expression survived for 3 years, while only 54% of those with low miR-218 expression survived.

conclusionmiR-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage, grade and metastasis. Serum expression of miR-218 may be a prognostic marker.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCase-Control StudiesCell DifferentiationDown-RegulationFemaleHumansKaplan-Meier EstimateMaleMicroRNAsMiddle AgedNeoplasm GradingNeoplasm InvasivenessNeoplasm StagingBiomarkers, TumorMicroRNAsMIRN218 microRNA, humanGastric cancerInvasionmicroRNA-218Prognosis

Identifiers

PMID24944481
PMCPMC4051930

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.