ArticleJournal of neurophysiology2014
Organization of pontine reticulospinal inputs to motoneurons controlling axial and limb muscles in the neonatal mouse.
Article in Journal of neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Multimodal cortical and subcortical exercise compared with treadmill training for spinal cord injury.PloS one · 2018Trial
- Hodological patterning as an organizing principle in vertebrate motor circuitry.Frontiers in neuroanatomy · 2024Review
- Functional organization of vestibulospinal inputs responsible for tail postural control in larvalFrontiers in neurology · 2024Article
- Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks.Nature communications · 2023Article
- Corrigendum: A Student's Guide to Neural Circuit Tracing.Frontiers in neuroscience · 2020Article
- Crossed activation of thoracic trunk motoneurons by medullary reticulospinal neurons.Journal of neurophysiology · 2019Article
- A Student's Guide to Neural Circuit Tracing.Frontiers in neuroscience · 2019Review
- Influence of Brain Stem on Axial and Hindlimb Spinal Locomotor Rhythm Generating Circuits of the Neonatal Mouse.Frontiers in neuroscience · 2018Article
- Human Postural Control.Frontiers in neuroscience · 2018Review
- The neural control of interlimb coordination during mammalian locomotion.Journal of neurophysiology · 2017Review
- Pontine reticulospinal projections in the neonatal mouse: Internal organization and axon trajectories.The Journal of comparative neurology · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Using optical recording of synaptically mediated calcium transients and selective spinal lesions, we investigated the pattern of activation of spinal motoneurons (MNs) by the pontine reticulospinal projection in isolated brain stem-spinal cord preparations from the neonatal mouse. Stimulation sites throughout the region where the pontine reticulospinal neurons reside reliably activated MNs at cervical, thoracic, and lumbar levels. Activation was similar in MNs ipsi- and contralateral to the stimulation site, similar in medial and lateral motor columns that contain trunk and limb MNs, respectively, and similar in the L2 and L5 segments that predominantly contain flexor and extensor MNs, respectively. In nonlesioned preparations, responses in both ipsi- and contralateral MNs followed individual stimuli in stimulus trains nearly one-to-one (with few failures). After unilateral hemisection at C1 on the same side as the stimulation, responses had substantially smaller magnitudes and longer latencies and no longer followed individual stimuli. After unilateral hemisection at C1 on the side opposite to the stimulation, the responses were also smaller, but their latencies were not affected. Thus we distinguish two pontine reticulospinal pathways to spinal MNs, one uncrossed and the other crossed, of which the uncrossed pathway transmits more faithfully and appears to be more direct.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.