SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2014
Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- A meta-analysis of the long-term outcomes following surgery or endoscopic therapy for chronic pancreatitis.Langenbeck's archives of surgery · 2022Pooled it
- Which Surgeries Are the Best Choice for Chronic Pancreatitis: A Network Meta-Analysis of Randomized Controlled Trials.Frontiers in surgery · 2021Pooled it
- A Comparative Study on Quality of Life Between Primary Early Surgery and Late Surgery in Chronic Calcific Pancreatitis using the SF-36 Questionnaire-A Prospective Observational Cohort Study.Digestive diseases and sciences · 2026Observational
- Comparative analysis of early outcomes in laparoscopic and open surgery for chronic pancreatitis: a retrospective study.Updates in surgery · 2026Article
- Chronic pancreatitis: how does surgery step in?Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Stent Patency and Survival after PTBD and Biliary Stenting for Pancreatic Cancer: A 5-Year Retrospective Cohort Study.Archives of Iranian medicine · 2025Article
- 16. Pain in chronic pancreatitis.Pain practice : the official journal of World Institute of Pain · 2025Review
- Surgical treatment of chronic pancreatitis with an inflammatory pancreatic head mass: a retrospective study.BMC gastroenterology · 2024Article
- Pain management in chronic pancreatitis.World journal of clinical cases · 2024Article
- Outcomes after Frey's procedure for chronic pancreatitis: a 8-year single-center experience in Colombia.BMC surgery · 2022Article
- Evidence-based clinical practice guidelines for chronic pancreatitis 2021.Journal of gastroenterology · 2022Review
- Complications of chronic pancreatitis prior to and following surgical treatment: A proposal for classification.World journal of clinical cases · 2022Article
- Surgery for chronic pancreatitis in Finland is rare but seems to produce good long-term results.World journal of clinical cases · 2021Article
- Review
- Russian Consensus on Exo- and Endocrine Pancreatic Insufficiency After Surgical Treatment.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- A Network Meta-analysis of Surgery for Chronic Pancreatitis: Impact on Pain and Quality of Life.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Review
- Bile duct preserving pancreatic head resection (BDPPHR): Can we conclusively define the extent of head resection in surgery for chronic pancreatitis?Annals of hepato-biliary-pancreatic surgery · 2020Article
- Impact of prior interventional treatment on the complications after Frey procedure for chronic pancreatitis.Langenbeck's archives of surgery · 2019Article
- The drain fluid amylase level on the first postoperative day predicts pancreatic fistula in chronic pancreatitis patients undergoing Frey procedure.Annals of hepato-biliary-pancreatic surgery · 2019Article
- Laparoscopic longitudinal pancreatojejunostomy and modified Frey's operation for chronic calcific pancreatitis.BJS open · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSurgical intervention has traditionally been reserved as the last management option for pain in chronic pancreatitis. Recently, there has been a call for surgery to be offered earlier in the disease process. The objectives of this review were to evaluate the effect of early surgery on postoperative pain, pancreatic function, and re-intervention rates in chronic pancreatitis.
methodsA systematic literature search through EMBASE, Cochrane Review, and PubMed from January 1950 to January 2014 was conducted. Citations found in relevant papers are hand-searched. Data which could be pooled were analyzed using Revman (v5.2). Risk of bias analysis was conducted.
resultsOf the 2,886 potentially eligible studies identified, 11 studies met the inclusion criteria. There was large heterogeneity in the study designs, and studies were conducted over a lengthy time span. Seven studies examined pain, three studies examined pancreatic function, and three studies examined rates of re-intervention. Meta-analysis of the three studies with comparative raw data regarding complete pain relief showed that early surgery was associated with an increased likelihood of complete postoperative pain relief (RR = 1.67, 95% CI 1.09-2.56, p = 0.02). Early surgery was also associated with reduced risk of pancreatic insufficiency and low re-intervention rates.
conclusionsData from this study supports considering early surgery for pain management in patients with chronic pancreatitis, with the potential of a reduced risk of pancreatic insufficiency and the need for further intervention. Further prospective randomized studies are warranted comparing early surgery against conservative step-up approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.