Evidence map›Paper›PMID 24944054›Full record

Trial reportThe American journal of clinical nutrition2014

Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: a randomized controlled-feeding trial.

Kristina Harris Jackson, Sheila G West, John P Vanden Heuvel, Satya S Jonnalagadda, Alastair B Ross, Alison M Hill, Jessica A Grieger, Susan K Lemieux, Penny M Kris-Etherton

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 10 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 10 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kristina Harris JacksonFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Sheila G WestFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
John P Vanden HeuvelFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Satya S JonnalagaddaFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Alastair B RossFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Alison M HillFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Jessica A GriegerFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Susan K LemieuxFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
Penny M Kris-EthertonFrom the Departments of Nutritional Sciences (KHJ, SGW, AMH, JAG, and PMK-E), Biobehavioral Health (SGW), and Veterinary and Biomedical Science (JPVH); the Center of Excellence in Nutrigenomics (JPVH and PMK-E); and the Social, Life, and Engineering Sciences Imaging Center (SKL), Pennsylvania State University, University Park, PA; the Bell Institute of Health and Nutrition, General Mills Inc, Minneapolis, MN (SSJ); the Nestlé Research Center, Lausanne, Switzerland (ABR); the Chalmers University of Technology, Gothenburg, Sweden (ABR); the Nutritional Physiology Research Centre, University of South Australia, Adelaide, Australia (AMH); and the Robinson Institute, Adelaide University, Adelaide, Australia (JAG).
General Mills (United States) · US

Funding

WRITING AND THE DAILY EXPERIENCE OF ILLNESSM01RR010732 · NCRR · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LOHSE, BARBARA · 1995 to 2009
$29.8M
NCRR NIH HHS M01RR10732
6 · The paper itself

Abstract

backgroundHigher whole-grain (WG) intake is associated with a lower prevalence of metabolic syndrome (MetS); however, there is inconsistent clinical evidence with regard to the benefit of WGs compared with refined grains (RGs) on MetS.

objectiveWe hypothesized that consuming WGs in the place of RGs would improve MetS criteria in individuals with or at risk of MetS.

designA randomized, controlled, open-label parallel study was conducted in 50 overweight and obese individuals with increased waist circumference and one or more other MetS criteria. Participants consumed a controlled weight-loss diet containing either WG or RG (control) products for 12 wk. Body composition, MetS criteria and related markers, and plasma alkylresorcinols (compliance marker of WG intake) were measured at baseline and at 6 and 12 wk. A subgroup (n = 28) underwent magnetic resonance imaging to quantify subcutaneous and visceral adipose tissue (AT).

resultsBaseline variables were not significantly different between groups; however, the RG group tended to have higher triglycerides and lower high-density lipoprotein (HDL) cholesterol (P = 0.06). Alkylresorcinols increased with consumption of the WG diet and did not change with consumption of the RG diet (time × treatment, P < 0.0001), which showed dietary compliance. There were no differences in anthropometric changes between groups; however, weight, body mass index, and percentage of body AT decreased at both 6 and 12 wk (P < 0.05), and reductions in percentage of abdominal AT occurred by 6 wk and did not change between 6 and 12 wk (P = 0.09). Both glucose (P = 0.02) and HDL cholesterol (P = 0.04) were lower with the consumption of the WG compared with the RG diet. However, when noncompliant individuals (n = 3) were removed, the glucose effect was stronger (P = 0.01) and the HDL-cholesterol effect was no longer significant (P = 0.14).

conclusionsReplacing RGs with WGs within a weight-loss diet does not beneficially affect abdominal AT loss and has modest effects on markers of MetS. WGs appear to be effective at normalizing blood glucose concentrations, especially in those individuals with prediabetes.

Indexed as

Diet, ReducingFood HandlingAdiposityAdultBiomarkersBody Mass IndexCholesterol, HDLEdible GrainFemaleHumansHypertriglyceridemiaMaleMetabolic SyndromeMiddle AgedObesityOverweightBiomarkersCholesterol, HDLResorcinols

Identifiers

PMID24944054
PMCPMC4095661
OpenAlexW2156980006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.