ReviewImmunology2014
'As above, so below' examining the interplay between emotion and the immune system.
Review in Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 69 citations in OpenAlex.
- Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy.Mediators of inflammation · 2018Trial
- Associations of cMIND Diet with depressive and anxiety symptoms among old people in China: a nationwide study.European journal of nutrition · 2025Article
- Motivating Protective Behavior against COVID-19: Fear Versus Hope.Journal of aging and health · 2024Article
- Identification of symptom clusters and sentinel symptoms during the first cycle of chemotherapy in patients with lung cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Comparative rhythmic transcriptome profiling of human and mouse striatal subregions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
- Blue Light Blocking Treatment for the Treatment of Bipolar Disorder: Directions for Research and Practice.Journal of clinical medicine · 2022Review
- Tumor suppression and improvement in immune systems by specific activation of dopamine D1-receptor-expressing neurons in the nucleus accumbens.Molecular brain · 2022Article
- Review on the Effect of Exercise Training on Immune Function.BioMed research international · 2022Review
- Animal Welfare and Resistance to Disease: Interaction of Affective States and the Immune System.Frontiers in veterinary science · 2022Article
- A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.Nature human behaviour · 2021Article
- Evidence of anticipatory immune and hormonal responses to predation risk in an echinoderm.Scientific reports · 2021Article
- Removal of vasopressin cells from the paraventricular nucleus of the hypothalamus enhances lipopolysaccharide-induced sickness behaviour in mice.Journal of neuroendocrinology · 2021Article
- Inflammation and Depression: the Neuroimmune Connection.Current treatment options in psychiatry · 2018Article
- γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.Journal of neuroinflammation · 2017Article
- Affective immunology: where emotions and the immune response converge.Dialogues in clinical neuroscience · 2017Review
- CD4(+) T cells confer anxiolytic and antidepressant-like effects, but enhance fear memory processes in Rag2(-/-) mice.Stress (Amsterdam, Netherlands) · 2016Article
- Massage-like stroking boosts the immune system in mice.Scientific reports · 2015Article
- The Anxiety Depression Pathway Among Men Following a Prostate Cancer Diagnosis: Cross-Sectional Interactions Between Anger Responses and Loneliness.American journal of men's healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the concept of a palpable relationship between our mental and physical well-being is certainly not new, it is only in the light of modern scientific research that we have begun to realize how deeply connected our emotional and immune states may be. We begin this review with a series of studies demonstrating how four fundamental emotional responses: anger, anxiety, mirth and relaxation are able modulate cytokine production and cellular responses to a variety of immune stimuli. These modulations are shown to be either detrimental or beneficial to a patient's health dependent on the context and duration of the emotion. We also discuss the reverse, highlighting research demonstrating how the loss of key immune cells such as T lymphocytes in clinical and animal studies can negatively impact both emotional well-being and cognition. Additionally, to give a more complete picture of the manifold pathways that link emotion and the immune system, we give a brief overview of the influence the digestive system has upon mental and immunological health. Finally, throughout this review we attempt to highlight the therapeutic potential of this burgeoning field of research in both the diagnosis and treatment of immune and disorders. As well as identifying some of the key obstacles the field must address in order to put this potential into practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.