ArticleArthritis & rheumatology (Hoboken, N.J.)2014
Brief Report: identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy.
Article in Arthritis & rheumatology (Hoboken, N.J.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Research progress of T cell autophagy in autoimmune diseases.Frontiers in immunology · 2024Review
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- Autophagy pathways in autoimmune diseases.Journal of autoimmunity · 2023Review
- Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis.Translational research : the journal of laboratory and clinical medicine · 2022Review
- Whole Exome Sequencing in a Population With Severe Congenital Anomalies of Kidney and Urinary Tract.Frontiers in pediatrics · 2022Article
- Glomerular galactose-deficient IgA1 expression analysis in pediatric patients with glomerular diseases.Scientific reports · 2020Article
- Comprehensive analysis of aberrantly expressed profiles of mRNA and its relationship with serum galactose-deficient IgA1 level in IgA nephropathy.Journal of translational medicine · 2019Article
- Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients.Scientific reports · 2019Article
- Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance.Disease models & mechanisms · 2019Article
- Article
- Increased autophagy is cytoprotective against podocyte injury induced by antibody and interferon-α in lupus nephritis.Annals of the rheumatic diseases · 2018Article
- A Rare Variant (rs933717) at FBXO31-MAP1LC3B in Chinese Is Associated With Systemic Lupus Erythematosus.Arthritis & rheumatology (Hoboken, N.J.) · 2018Article
- UCH-L1 Expressed by Podocytes: a Potentially Therapeutic Target for Lupus Nephritis?Inflammation · 2017Review
- Autophagy-related gene LRRK2 is likely a susceptibility gene for systemic lupus erythematosus in northern Han Chinese.Oncotarget · 2017Article
- Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations.Scientific reports · 2017Article
- IL-1Journal of immunology research · 2017Article
- Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy.Scientific reports · 2016Article
- Insights into kidney diseases from genome-wide association studies.Nature reviews. Nephrology · 2016Review
- Autophagy in Chronic Kidney Diseases.Kidney diseases (Basel, Switzerland) · 2016Review
- Single-nucleotide polymorphisms in the PLA2R1 gene are associated with systemic lupus erythematosus and lupus nephritis in a Chinese Han population.Immunologic research · 2016Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveSeveral novel susceptibility genes for systemic lupus erythematosus (SLE) and IgA nephropathy have been identified in recent genome-wide association studies. Since both lupus nephritis and IgA nephropathy are autoimmune diseases of the kidney, they may share common disease mechanisms that overlap with genetic susceptibility. To test this hypothesis, we sought to identify genetic variants associated with IgA nephropathy in lupus nephritis.
methodsIn the first stage, 500 patients with lupus nephritis, 240 SLE patients without nephritis, and 500 healthy controls were enrolled. Fifteen single-nucleotide polymorphisms (SNPs) that had the topmost association signals with IgA nephropathy were selected for further testing in patients with lupus nephritis. Three independent cohorts from Beijing, Shanghai, and Hong Kong were included as replicates. We also analyzed the functional significance of identified noncoding variants on regulatory motifs and gene expression. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
resultsIn addition to associations with HLA gene polymorphisms, genetic variants of MTMR3 in 22q12 showed associations with lupus nephritis (for rs9983A, OR 1.61 [95% CI 1.19-2.19], P = 2.07 × 10(-3) ) compared to healthy controls in the first stage. Associations were replicated and reinforced among northern Han Chinese (for lupus nephritis patients versus SLE patients without nephritis, P = 0.01) but not southern Han Chinese, although significant genetic heterogeneity was observed. Conservative and regulatory features of rs9983 were predicted in in silico analyses. In expression analysis, we observed lower MTMR3 transcription levels in samples of blood with rs9983A and in renal biopsy samples from lupus nephritis and IgA nephropathy patients.
conclusionOur results suggest that the MTMR3 gene is shared between IgA nephropathy and lupus nephritis in the northern Chinese population, further highlighting the role of autophagy in SLE. However, widespread replication of these experiments, fine mapping, and functional assays are required to establish this connection.
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