ArticleMolecular biology of the cell2014
Mathematical model with spatially uniform regulation explains long-range bidirectional transport of early endosomes in fungal hyphae.
Article in Molecular biology of the cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties.Frontiers in cell and developmental biology · 2024Review
- Correlated random walks inside a cell: actin branching and microtubule dynamics.Journal of mathematical biology · 2019Article
- Spatial organization of organelles in fungi: Insights from mathematical modelling.Fungal genetics and biology : FG & B · 2017Review
- Spatial pattern formation in microtubule post-translational modifications and the tight localization of motor-driven cargo.Journal of mathematical biology · 2017Article
- Active diffusion and microtubule-based transport oppose myosin forces to position organelles in cells.Nature communications · 2016Article
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Authors and funding
3 authors.
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Abstract
In many cellular contexts, cargo is transported bidirectionally along microtubule bundles by dynein and kinesin-family motors. Upstream factors influence how individual cargoes are locally regulated, as well as how long-range transport is regulated at the whole-cell scale. Although the details of local, single-cargo bidirectional switching have been extensively studied, it remains to be elucidated how this results in cell-scale spatial organization. Here we develop a mathematical model of early endosome transport in Ustilago maydis. We demonstrate that spatiotemporally uniform regulation, with constant transition rates, results in cargo dynamics that is consistent with experimental data, including data from motor mutants. We find that microtubule arrays can be symmetric in plus-end distribution but asymmetric in binding-site distribution in a manner that affects cargo dynamics and that cargo can travel past microtubule ends in microtubule bundles. Our model makes several testable predictions, including secondary features of dynein and cargo distributions.
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