Evidence map›Paper›PMID 24943487›Full record

ArticleStem cell reviews and reports2014

Human adipose tissue derived pericytes increase life span in Utrn (tm1Ked) Dmd (mdx) /J mice.

M C Valadares, J P Gomes, G Castello, A Assoni, M Pellati, C Bueno, M Corselli, H Silva, P Bartolini, M Vainzof and 4 more

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In one paragraph

Article in Stem cell reviews and reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Urine-derived stem cells genetically modified with IGF1 improve muscle regeneration.American journal of clinical and experimental urology · 2024
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Pericytes in Muscular Dystrophies.Advances in experimental medicine and biology · 2019
    Article
  11. Article
  12. Exosomes Released by Gastric Cancer Cells Induce Transition of Pericytes Into Cancer-Associated Fibroblasts.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

M C ValadaresHuman Genome and stem-cell Center, Institute of Biosciences, University of São Paulo, Rua do Matāo 106, São Paulo, CEP 05508-030, Brazil.
J P Gomes
G Castello
A Assoni
M Pellati
C Bueno
M Corselli
H Silva
P Bartolini
M Vainzof
P F Margarido
E Baracat
B Péault
M Zatz
Universidade de São Paulo · BROrthopaedic Hospital · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRHospital Universitário da Universidade de São Paulo · BRNational Nuclear Energy Commission · BRUniversidade Federal de São Paulo · BR

Funding

Medical Research Council G1000816
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is still an untreatable lethal X-linked disorder, which affects 1 in 3500 male births. It is caused by the absence of muscle dystrophin due to mutations in the dystrophin gene. The potential regenerative capacity as well as immune privileged properties of mesenchymal Stem Cells (MSC) has been under investigation for many years in an attempt to treat DMD. One of the questions to be addressed is whether stem cells from distinct sources have comparable clinical effects when injected in murine or canine muscular dystrophy animal models. Many studies comparing different stem cells from various sources were reported but these cells were obtained from different donors and thus with different genetic backgrounds. Here we investigated whether human pericytes obtained from 4 different tissues (muscle, adipose tissue, fallopian tube and endometrium) from the same donor have a similar clinical impact when injected in double mutant Utrn (tm1Ked) Dmd (mdx) /J mice, a clinically relevant model for DMD. After a weekly regimen of intraperitoneal injections of 10(6) cells per 8 weeks we evaluated the motor ability as well as the life span of the treated mice as compared to controls. Our experiment showed that only adipose tissue derived pericytes are able to increase significantly (39 days on average) the life span of affected mice. Microarray analysis showed an inhibition of the interferon pathway by adipose derived pericytes. Our results suggest that the clinical benefit associated with intraperitoneal injections of these adult stem cells is related to immune modulation rather than tissue regeneration.

Indexed as

Adipose TissueAnimalsCell DifferentiationCells, CulturedDisease Models, AnimalDystrophinFemaleHumansMesenchymal Stem CellsMiceMice, Inbred mdxMiddle AgedMuscle, SkeletalMuscular Dystrophy, DuchennePericytesDystrophin

Identifiers

PMID24943487
OpenAlexW2117956343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.