ArticleProceedings. Biological sciences2014
Independently recruited oxidases from the glucose-methanol-choline oxidoreductase family enabled chemical defences in leaf beetle larvae (subtribe Chrysomelina) to evolve.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Characterization of Chemical Defensive Behavior and Associated Glands in the Destructive Invasive Longhorn BeetleInsects · 2026Article
- Multi-omic insights into the formation and evolution of a novel shell microstructure in oysters.BMC biology · 2023Article
- A salivary GMC oxidoreductase of Manduca sexta re-arranges the green leaf volatile profile of its host plant.Nature communications · 2023Article
- Biosynthesis of iridoid sex pheromones in aphids.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A GMC Oxidoreductase GmcA Is Required for Symbiotic Nitrogen Fixation inFrontiers in microbiology · 2020Article
- Genes Involved in Stress Response and Especially in Phytoalexin Biosynthesis Are Upregulated in FourFrontiers in plant science · 2019Article
- Genomics and Comparative Genomic Analyses Provide Insight into the Taxonomy and Pathogenic Potential of NovelFrontiers in cellular and infection microbiology · 2017Article
- A common theme in extracellular fluids of beetles: extracellular superoxide dismutases crucial for balancing ROS in response to microbial challenge.Scientific reports · 2016Article
- Article
- Redefining metamorphosis in spiny lobsters: molecular analysis of the phyllosoma to puerulus transition in Sagmariasus verreauxi.Scientific reports · 2015Article
- Mechanisms and ecological consequences of plant defence induction and suppression in herbivore communities.Annals of botany · 2015Review
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8 authors.
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Abstract
Larvae of the leaf beetle subtribe Chrysomelina sensu stricto repel their enemies by displaying glandular secretions that contain defensive compounds. These repellents can be produced either de novo (iridoids) or by using plant-derived precursors (e.g. salicylaldehyde). The autonomous production of iridoids, as in Phaedon cochleariae, is the ancestral chrysomeline chemical defence and predates the evolution of salicylaldehyde-based defence. Both biosynthesis strategies include an oxidative step of an alcohol intermediate. In salicylaldehyde-producing species, this step is catalysed by salicyl alcohol oxidases (SAOs) of the glucose-methanol-choline (GMC) oxidoreductase superfamily, but the enzyme oxidizing the iridoid precursor is unknown. Here, we show by in vitro as well as in vivo experiments that P. cochleariae also uses an oxidase from the GMC superfamily for defensive purposes. However, our phylogenetic analysis of chrysomeline GMC oxidoreductases revealed that the oxidase of the iridoid pathway originated from a GMC clade different from that of the SAOs. Thus, the evolution of a host-independent chemical defence followed by a shift to a host-dependent chemical defence in chrysomeline beetles coincided with the utilization of genes from different GMC subfamilies. These findings illustrate the importance of the GMC multi-gene family for adaptive processes in plant-insect interactions.
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