Evidence map›Paper›PMID 24943201›Full record

ReviewJournal of dental research2014

Review of preclinical studies on treatment of mucositis and associated pain.

C T Viet, P M Corby, A Akinwande, B L Schmidt

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Heparin treatment mitigates radiation-induced oral mucositis in mice by interplaying with repopulation processes.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2019
    Article
  11. [EGFR-TKI ADR Management Chinese Expert Consensus].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019
    Article
  12. Article
  13. Systemic administration of heparin ameliorates radiation-induced oral mucositis-preclinical studies in mice.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2018
    Article
  14. Article
  15. Review
  16. Cancer and orofacial pain.Medicina oral, patologia oral y cirugia bucal · 2016
    Review
  17. Article
  18. Modulation of radiation-induced oral mucositis by thalidomide : Preclinical studies.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

C T VietBluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Oral and Maxillofacial Surgery, New York University, College of Dentistry, NY, USA.
P M CorbyBluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Periodontics, New York University, College of Dentistry, NY, USA.
A AkinwandeBluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA.
B L SchmidtBluestone Center for Clinical Research, New York University, College of Dentistry, NY, USA Department of Oral and Maxillofacial Surgery, New York University, College of Dentistry, NY, USA bls322@nyu.edu.
Center for Clinical Research (United States) · USNew York University · US

Funding

The Role of Proteases and Peptides in Cancer PainR01DE019796 · NIDCR · NEW YORK UNIVERSITY · PI HARDT, MARKUS, SCHMIDT, BRIAN L · 2010 to 2014
$2.8M
NIDCR NIH HHS R01 DE019796NIDCR NIH HHS R01 DE19796
6 · The paper itself

Abstract

Oral mucositis is a significant problem in cancer patients treated with radiation or chemotherapy, often hindering definitive cancer treatment. For patients with oral mucositis, pain is the most distressing symptom, leading to loss of orofacial function and poor quality of life. While oral mucositis has been well-described, its pathophysiology is poorly understood. Oral health professionals treating patients with mucositis have almost no effective therapies to treat or prevent oral mucositis. The purpose of this review is to (1) describe the current preclinical models of oral mucositis and their contribution to the understanding of mucositis pathophysiology, (2) explore preclinical studies on therapies targeting mucositis and discuss the clinical trials that have resulted from these preclinical studies, and (3) describe the proposed pathophysiology of oral mucositis pain and preclinical modeling of oral mucositis pain.

Indexed as

AnalgesicsAnimalsDisease Models, AnimalDrug Evaluation, PreclinicalHead and Neck NeoplasmsHumansNeuralgiaNociceptorsPainStomatitisAnalgesicscancer complicationscancer symptomsmucositis modelsmucositis treatmentoral painstomatitis

Identifiers

PMID24943201
PMCPMC4213248
OpenAlexW2160416386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.