Evidence map›Paper›PMID 24943053›Full record

ReviewNeurobiology of disease2014

Structural and functional correlates of epileptogenesis - does gender matter?

Ivanka Savic, Jerome Engel

Abstract readReview
In one paragraph

Review in Neurobiology of disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. A comparative cohort study of epilepsy in children in Greenland and Denmark.International journal of circumpolar health · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Frontiers of medicine · 2021
    Article
  10. Review
  11. Observational
  12. Review
  13. Review
  14. Article
  15. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ivanka SavicDepartment of Women's and Children's Health, Karolinska Institute and Neurology Clinic, Karolinska University Hospital, Sweden. Electronic address: ivanka.savic-berglund@ki.se.
Jerome EngelDepartment of Neurology, David Geffen School of Medicine at UCLA, USA; Department of Neurobiology, David Geffen School of Medicine at UCLA, USA; Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, USA; The Brain Research Institute, David Geffen School of Medicine at UCLA, USA.

Funding

SYSTEMS PATHOPHYSIOLOGYP01NS002808 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE · 1985 to 2010
$13.5M
Early Randomized Surgical Epilepsy TrialU01NS042372 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE · 2002 to 2007
$9.8M
IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR01NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME NONE ENGEL, Richard Staba · 1994 to 2026
$7.5M
IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR37NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE · 2004 to 2010
$3.2M
The Epilepsy Bioinformatics Study (EpiBioS)P20NS080181 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, HOVDA, DAVID A · 2012 to 2014
$1.7M
NINDS NIH HHS P01 NS002808NINDS NIH HHS P01 NS02808NINDS NIH HHS P20 NS080181NINDS NIH HHS P20 NS 80181NINDS NIH HHS R01 NS033310NINDS NIH HHS R01 NS33310NINDS NIH HHS R37 NS033310NINDS NIH HHS U01 NS042372NINDS NIH HHS U01 NS42372
6 · The paper itself

Abstract

In the majority of neuropsychiatric conditions, marked gender-based differences have been found in the epidemiology, clinical manifestations, and therapy of disease. One possible reason is that sex differences in cerebral morphology, structural and functional connections, render men and women differentially vulnerable to various disease processes. The present review addresses this issue with respect to the functional and structural correlates to some forms of epilepsy.

Indexed as

Sex CharacteristicsAnimalsBrainEpilepsyFemaleHumansMaleCerebral connectivityGeneralized epilepsyMRIMTLESeizuresSex difference

Identifiers

PMID24943053
PMCPMC5003532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.