ArticleMolecular pain2014
Decreased pain threshold and enhanced synaptic transmission in the anterior cingulate cortex of experimental hypothyroidism mice.
Article in Molecular pain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06649318 (Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Brain GABA Metabolite Amount to Propofol Utilisation Under TIVA in Hypothyroid Patient
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Brain functional connectivity in hyperthyroid patients: systematic review.Frontiers in neuroscience · 2024Pooled it
- Trial
- Cross-sectional study and clinical prediction of post-thyroidectomy discomfort.Gland surgery · 2026Article
- Neurological consequences of adult-onset hypothyroidism.Endocrine journal · 2025Review
- Thyroid-stimulating hormone induces insulin resistance in adipocytes via endoplasmic reticulum stress.Endocrine connections · 2024Article
- Effect of thiamazole on kainic acid-induced seizures in mice.Saudi journal of biological sciences · 2021Article
- Congenital Hypothyroidism and Brain Development: Association With Other Psychiatric Disorders.Frontiers in neuroscience · 2021Review
- Brain GABA+ changes in primary hypothyroidism patients before and after levothyroxine treatment: A longitudinal magnetic resonance spectroscopy study.NeuroImage. Clinical · 2020Article
- Differential Role of Anterior Cingulate Cortical Glutamatergic Neurons in Pain-Related Aversion Learning and Nociceptive Behaviors in Male and Female Rats.Frontiers in behavioral neuroscience · 2020Article
- Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction.The Journal of international medical research · 2020Article
- Effects of Sub-Acute Manganese Exposure on Thyroid Hormone and Glutamine (Gln)/Glutamate (Glu)-γ- Aminobutyric Acid (GABA) Cycle in Serum of Rats.International journal of environmental research and public health · 2019Article
- Role of thyroid dysimmunity and thyroid hormones in endometriosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Investigation of brain GABA+ in primary hypothyroidism using edited proton MR spectroscopy.Clinical endocrinology · 2017Article
- Physical Activity May Be Associated with Conditioned Pain Modulation in Women but Not Men among Healthy Individuals.Pain research & management · 2017Article
- When Headache Warns of Homeostatic Threat: the Metabolic Headaches.Current neurology and neuroscience reports · 2017Review
- Article
- Cerebral Perfusion and Gray Matter Changes Associated With Chemotherapy-Induced Peripheral Neuropathy.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThyroid hormones are essential for the maturation and functions of the central nervous system. Pain sensitivity is related to the thyroid status. However, information on how thyroid hormones affect pain processing and synaptic transmission in the anterior cingulate cortex (ACC) is limited. Nociceptive threshold and synaptic transmission in the ACC were detected in the experimental hypothyroidism (HT) mice.
resultsHT was induced by methimazole and potassium perchlorate in distilled drinking water for 4 weeks. The threshold of pain perception to hot insults, but not mechanical ones, decreased in hypothyroid mice. After treatment with tri-iodothyronine (T3) or thyroxine (T4) for 2 weeks, thermal pain threshold recovered. Electrophysiological recordings revealed enhanced glutamatergic synaptic transmission and reduced GABAergic synaptic transmission in the ACC. Supplementation with T3 or T4 significantly rescued this synaptic transmission imbalance. In the same model, HT caused the up-regulation of the GluR1 subunit of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor and NR2B-containing N-methyl-D-aspartate receptors, but it down-regulated γ-aminobutyric acid A receptors in the ACC. Supplementation with T3 or T4 notably recovered the levels of above proteins.
conclusionsThese results suggest that HT promotes hypersensitivity to noxious thermal, and that supplementation with T3 or T4 rescues the imbalance between excitatory and inhibitory transmission in the ACC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.