Evidence map›Paper›PMID 24942913›Full record

ArticleInflammation2014

Insulin-like growth factor 1 treatment of MSCs attenuates inflammation and cardiac dysfunction following MI.

Jun Guo, Dong Zheng, Wen-feng Li, Hai-rui Li, Ai-dong Zhang, Zi-cheng Li

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

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  5. International journal of molecular sciences · 2024
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  19. Stem cell death and survival in heart regeneration and repair.Apoptosis : an international journal on programmed cell death · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jun GuoDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, People's Republic of China, dr.guojun@163.com.
Dong Zheng
Wen-feng Li
Hai-rui Li
Ai-dong Zhang
Zi-cheng Li
First Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been reported that insulin-like growth factor 1 (IGF-1) promoted migration of endothelial cells and cardiac resident progenitor cells. In the previous study, we found the time-dependent and dose-dependent effects of IGF-1 treatment on the CXCR4 expression in MSCs in vitro, but it is still not clear whether IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation role in myocardial infarction. In this study, we demonstrated that IGF-1-treated MSCs' transplantation attenuate cardiac dysfunction, increase the survival of engrafted cells in the ischemic heart, decrease myocardium cells apoptosis, and inhibit protein production and gene expression of inflammation cytokines tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6. IGF-1 pretreatment of MSCs may play anti-apoptotic and anti-inflammation roles in post-myocardial infarction.

Indexed as

AnimalsCell SurvivalInflammationInsulin-Like Growth Factor IMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationMyocardial InfarctionRatsRats, Sprague-DawleyInsulin-Like Growth Factor I

Identifiers

PMID24942913
OpenAlexW1965863981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.