Evidence map›Paper›PMID 24942806›Full record

ReviewHeart failure reviews2015

Water and sodium in heart failure: a spotlight on congestion.

Gaspare Parrinello, Stephen J Greene, Daniele Torres, Michael Alderman, Joseph Vincent Bonventre, Pietro Di Pasquale, Luna Gargani, Anju Nohria, Gregg C Fonarow, Muthiah Vaduganathan and 4 more

Retracted Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Heart failure reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT06128655 (Developing and Testing a Nurse-Led Technology-Enhanced Family Engagement Program), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06128655 nacompletednot on this mapstarted 2024, after this paper: background citation

Developing and Testing a Nurse-Led Technology-Enhanced Family Engagement Program (NURSE-TECH-Family) Among Critically Ill Patients in ICU: A Randomized Controlled Trial

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2024 to 2025Enrolled29ConditionsCritical IllnessArmsParticipation in PFCC-IR
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 48 citations in OpenAlex.

  1. An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Thyrotoxic Cardiomyopathy: State of the Art.TouchREVIEWS in endocrinology · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Estimated plasma volume status in heart failure: clinical implications and future directions.Clinical research in cardiology : official journal of the German Cardiac Society · 2021
    Review
  16. Article
  17. Article
  18. Acute heart failure.Nature reviews. Disease primers · 2020 · on this map
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Gaspare ParrinelloBiomedical Department of Internal and Specialty Medicine (Di.Bi.M.I.S.), A.O.U.P "Paolo Giaccone", University of Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy, gaspare.parrinello@unipa.it.
Stephen J Greene
Daniele Torres
Michael Alderman
Joseph Vincent Bonventre
Pietro Di Pasquale
Luna Gargani
Anju Nohria
Gregg C Fonarow
Muthiah Vaduganathan
Javed Butler
Salvatore Paterna
Lynne Warner Stevenson
Mihai Gheorghiade
Harvard University · USUniversity of Palermo · ITNorthwestern University · USAlbert Einstein College of Medicine · USEmory University · USMassachusetts General Hospital · USNational Research Council · ITOspedale G.F. Ingrassia · ITRonald Reagan UCLA Medical Center · US

Funding

Mechanisms of Ischemic Kidney Injury and RepairR37DK039773 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT · 1993 to 2021
$5.2M
NIDDK NIH HHS R37 DK039773
6 · The paper itself

Abstract

Despite all available therapies, the rates of hospitalization and death from heart failure (HF) remain unacceptably high. The most common reasons for hospital admission are symptoms related to congestion. During hospitalization, most patients respond well to standard therapy and are discharged with significantly improved symptoms. Post-discharge, many patients receive diligent and frequent follow-up. However, rehospitalization rates remain high. One potential explanation is a persistent failure by clinicians to adequately manage congestion in the outpatient setting. The failure to successfully manage these patients post-discharge may represent an unmet need to improve the way congestion is both recognized and treated. A primary aim of future HF management may be to improve clinical surveillance to prevent and manage chronic fluid overload while simultaneously maximizing the use of evidence-based therapies with proven long-term benefit. Improvement in cardiac function is the ultimate goal and maintenance of a "dry" clinical profile is important to prevent hospital admission and improve prognosis. This paper focuses on methods for monitoring congestion, and strategies for water and sodium management in the context of the complex interplay between the cardiac and renal systems. A rationale for improving recognition and treatment of congestion is also proposed.

Indexed as

Body WaterBiomarkersCardio-Renal SyndromeDiureticsHeart FailureHospitalizationHumansKidneyPatient DischargePrognosisSodium, DietarySymptom AssessmentBiomarkersDiureticsSodium, Dietary

Identifiers

PMID24942806
PMCPMC4405162
OpenAlexW2037936453

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.