Evidence map›Paper›PMID 24942574›Full record

ArticleJournal of virology2014

Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.

Max Crispin, David J Harvey, David Bitto, Steinar Halldorsson, Camille Bonomelli, Matthew Edgeworth, James H Scrivens, Juha T Huiskonen, Thomas A Bowden

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Exploitation of glycosylation in enveloped virus pathobiology.Biochimica et biophysica acta. General subjects · 2019
    Review
  3. Article
  4. Article
  5. Article
  6. Structural principles controlling HIV envelope glycosylation.Current opinion in structural biology · 2017
    Review
  7. Article
  8. Review
  9. Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Max CrispinOxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom Max.Crispin@bioch.ox.ac.uk Thomas.Bowden@strubi.ox.ac.uk.
David J HarveyOxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom School of Life Sciences, University of Warwick, Coventry, United Kingdom.
David BittoDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Steinar HalldorssonDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Camille BonomelliOxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom.
Matthew EdgeworthSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
James H ScrivensSchool of Life Sciences, University of Warwick, Coventry, United Kingdom.
Juha T HuiskonenDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Thomas A BowdenDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom Max.Crispin@bioch.ox.ac.uk Thomas.Bowden@strubi.ox.ac.uk.
University of Oxford · GBUniversity of Warwick · GBCentre for Human Genetics · GB

Funding

Medical Research Council MR/L009528/1Wellcome Trust 089026/Z/09/ZWellcome Trust 090532Wellcome Trust 090532/Z/09/Z
6 · The paper itself

Abstract

Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.

Indexed as

Virus AssemblyVirus ReleaseGlucansGlycomicsGlycoproteinsHumansUukuniemi virusViral ProteinsVirionGlucansGlycoproteinsViral Proteins

Identifiers

PMID24942574
PMCPMC4136308
OpenAlexW2053624853

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.