ArticleJournal of virology2014
Isolation and characterization of a novel alphaherpesvirus in fruit bats.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Bat things come in threes: within-host dynamics of herpesvirus triple infection in bats.Journal of virology · 2025Article
- Herpesviruses: overview of systematics, genomic complexity and life cycle.Virology journal · 2025Review
- Rapid taxonomic categorization of short, abundant virus sequences for ecological analyses.Ecology and evolution · 2024Article
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- Attenuated infection by a Pteropine orthoreovirus isolated from an Egyptian fruit bat in Zambia.PLoS neglected tropical diseases · 2021Article
- Ecological and Conservation Significance of Herpesvirus Infection in Neotropical Bats.EcoHealth · 2021Article
- Novel herpesviruses in neotropical bats and their relationship with other members of the Herpesviridae family.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020Article
- Characterization of a Novel Alphaherpesvirus Isolated from the Fruit BatJournal of virology · 2020Article
- Detection of first gammaherpesvirus sequences in Central African bats.New microbes and new infections · 2020Article
- Genomic nucleotide-based distance analysis for delimiting old world monkey derived herpes simplex virus species.BMC genomics · 2020Article
- The spleen morphophysiology of fruit bats.Anatomia, histologia, embryologia · 2019Article
- Comparative analysis of serologic cross-reactivity using convalescent sera from filovirus-experimentally infected fruit bats.Scientific reports · 2019Article
- Bats, Primates, and the Evolutionary Origins and Diversification of Mammalian Gammaherpesviruses.mBio · 2016Article
- Article
- Divergent bufavirus harboured in megabats represents a new lineage of parvoviruses.Scientific reports · 2016Article
- The first genome sequence of a metatherian herpesvirus: Macropodid herpesvirus 1.BMC genomics · 2016Article
- High prevalence and diversity of viruses of the subfamily Gammaherpesvirinae, family Herpesviridae, in fecal specimens from bats of different species in southern China.Archives of virology · 2016Article
- Identification of Novel Betaherpesviruses in Iberian Bats Reveals Parallel Evolution.PloS one · 2016Article
- Bats as 'special' reservoirs for emerging zoonotic pathogens.Trends in microbiology · 2015Review
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledBats are known to harbor emerging RNA viruses. Recent studies have used high-throughput sequencing technology to identify various virus species, including DNA viruses that are harbored by bats; however, little is known about the nature of these potentially novel viruses. Here, we report the characterization of a novel herpesvirus isolated from an Indonesian pteropodid bat. The virus, tentatively named fruit bat alphaherpesvirus 1 (FBAHV1), has a double-stranded DNA genome of 149,459 bp. The phylogenetic analyses suggested that FBAHV1 is phylogenetically grouped with simplexviruses within the subfamily Alphaherpesvirinae. Inoculation of FBAHV1 into laboratory mice caused a lethal infection. Virus infection was observed in lung, liver, and brain tissue. Serological and PCR screening revealed that fruit bats infected with FBAHV1 or its related virus are widely distributed in Indonesia. The identification of FBAHV1 makes a considerable contribution to our understanding of simplexviruses associated with bats. IMPORTANCE: Bats are known to harbor emerging viruses, such as lyssaviruses, henipaviruses, severe acute respiratory syndrome-like coronaviruses, and filoviruses. Although alphaherpesviruses are disseminated in humans and other animals, there is little information about their distribution in bats. Here, we isolated a previously unknown alphaherpesvirus from an Indonesian fruit bat. Genome sequence analysis suggested that the virus is a member of the genus Simplexvirus within the subfamily Alphaherpesvirinae, which also includes common human viruses, such as herpes simplex virus 1 and herpes simplex virus 2. FBAHV1 is the first bat-derived alphaherpesvirus whose complete genome has been sequenced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.