ArticleAlcoholism, clinical and experimental research2014
Monkey alcohol tissue research resource: banking tissues for alcohol research.
Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 42 citations in OpenAlex.
- Alcohol drinking sex-dependently regulates interleukin-1 pro-inflammatory signaling in the prefrontal cortex of mice and rhesus macaques.Brain, behavior, and immunity · 2026Article
- Chronic ethanol self-administration alters dopamine in the caudate nucleus and putamen of rhesus macaques in a sex-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Chronic alcohol consumption disrupts the gut microbial and metabolic landscapes.Frontiers in microbiology · 2026Article
- Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates define neural vulnerability for future risky ethanol consumption.Neurobiology of disease · 2025Article
- Short-term heavy drinking in a non-human primate model skews monocytes toward a hypo-inflammatory phenotype.Frontiers in immunology · 2025Article
- Article
- Ethanol consumption in non-human primates alters plasma markers of bone turnover but not tibia architecture.Scientific reports · 2024Article
- Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques.Bone · 2024Article
- Effects of repeated alcohol abstinence on within-subject prefrontal cortical gene expression in rhesus macaques.Advances in drug and alcohol research · 2024Article
- Long-term drinking stability in the open-access self-administration monkey model.Alcohol (Fayetteville, N.Y.) · 2023Article
- Image processing approach provides robust feature extraction for classification with small sample sizes.Proceedings of the 2023 7th International Conference on Information System and Data Mining : Atlanta, GA, United States, May 10-12, 202. International Conference on Information System and Data Mining (7th : 2023 : Atlanta, Ga.) · 2023Article
- Ethanol alters the relationship between IGF-1 and bone turnover in male macaques.The Journal of endocrinology · 2022Article
- Somatic retrotransposition in the developing rhesus macaque brain.Genome research · 2022Article
- Dose-response effects of alcohol on biochemical markers of bone turnover in non-human primates: Effects of species, sex and age of onset of drinking.Bone reports · 2022Article
- Pairing food and drink: A physiological model of blood ethanol levels for a variety of drinking behaviors.Mathematical biosciences · 2022Article
- Neurobeachin, a promising target for use in the treatment of alcohol use disorder.Addiction biology · 2022Article
- Improving rigor and reproducibility in nonhuman primate research.American journal of primatology · 2021Review
- Between-subject and within-subject variability in measures of biochemical markers of bone turnover in cynomolgus and rhesus macaques.Bone reports · 2021Article
- Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome.Addiction biology · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAn estimated 18 million adults in the United States meet the clinical criteria for diagnosis of alcohol abuse or alcoholism, a disorder ranked as the third leading cause of preventable death. In addition to brain pathology, heavy alcohol consumption is comorbid with damage to major organs including heart, lungs, liver, pancreas, and kidneys. Much of what is known about risk for and consequences of heavy consumption derive from rodent or retrospective human studies. The neurobiological effects of chronic intake in rodent studies may not easily translate to humans due to key differences in brain structure and organization between species, including a lack of higher-order cognitive functions, and differences in underlying prefrontal cortical neural structures that characterize the primate brain. Further, rodents do not voluntarily consume large quantities of ethanol (EtOH) and they metabolize it more rapidly than primates.
methodsThe basis of the Monkey Alcohol Tissue Research Resource (MATRR) is that nonhuman primates, specifically monkeys, show a range of drinking excessive amounts of alcohol (>3.0 g/kg or a 12 drink equivalent per day) over long periods of time (12 to 30 months) with concomitant pathological changes in endocrine, hepatic, and central nervous system (CNS) processes. The patterns and range of alcohol intake that monkeys voluntarily consume parallel what is observed in humans with alcohol use disorders and the longitudinal experimental design spans stages of drinking from the EtOH-naïve state to early exposure through chronic abuse. Age- and sex-matched control animals self-administer an isocaloric solution under identical operant procedures.
resultsThe MATRR is a unique postmortem tissue bank that provides CNS and peripheral tissues, and associated bioinformatics from monkeys that self-administer EtOH using a standardized experimental paradigm to the broader alcohol research community.
conclusionsThis resource provides a translational platform from which we can better understand the disease processes associated with alcoholism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.