Evidence map›Paper›PMID 24942512›Full record

ArticleCritical care medicine2014

Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.

S Jean Hsieh, Hanjing Zhuo, Neal L Benowitz, B Taylor Thompson, Kathleen D Liu, Michael A Matthay, Carolyn S Calfee, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Biochemical verification of tobacco use in ICU patients using point-of-care urinary cotinine.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  5. Article
  6. Review
  7. The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.American journal of respiratory and critical care medicine · 2024
    Article
  8. Heliyon · 2023
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Environmental Factors.Critical care clinics · 2021
    Review
  14. Review
  15. Review
  16. Alternative Tobacco Product Use in Critically Ill Patients.International journal of environmental research and public health · 2020
    Article
  17. Article
  18. Effects of cigarette smoke on pulmonary endothelial cells.American journal of physiology. Lung cellular and molecular physiology · 2018
    Review
  19. Pulmonary Endothelial Cell Apoptosis in Emphysema and Acute Lung Injury.Advances in anatomy, embryology, and cell biology · 2018
    Review
  20. Alda-1 Protects Against Acrolein-Induced Acute Lung Injury and Endothelial Barrier Dysfunction.American journal of respiratory cell and molecular biology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

S Jean Hsieh1Division of Critical Care Medicine, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY. 2Cardiovascular Research Institute, University of California, San Francisco, CA. 3Division of Clinical Pharmacology and Experimental Therapeutics, University of California, San Francisco, CA. 4Center for Tobacco Control Research and Education, University of California, San Francisco, CA. 5Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA. 6Division of Nephrology, Department of Medicine, University of California, San Francisco, CA. 7Department of Anesthesia, University of California, San Francisco, CA. 8Division of Pulmonary and Critical Care, Department of Medicine, University of California, San Francisco, CA.
Hanjing Zhuo
Neal L Benowitz
B Taylor Thompson
Kathleen D Liu
Michael A Matthay
Carolyn S Calfee
National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network
National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network
Apple (Israel) · IL

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Research Support CoreP30DA012393 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JACOB, PEYTON · 1999 to 2024
$17.1M
Resolution of Clinical Lung InjuryR37HL051856 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2006 to 2015
$3.9M
Cigarette Smoke Exposure and Acute Lung Injury After Severe Blunt TraumaR01HL110969 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2012 to 2016
$1.9M
RESOLUTION OF CLINICAL LUNG INJURYR01HL051856 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 1996 to 2005
$1.7M
Clinical and Translational Science AwardKL2TR001071 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAMOON, HARRY · 2013 to 2017
$968k
Clinical and Translational Science AwardTL1TR001072 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SHAMOON, HARRY · 2013 to 2017
$909k
Impact of Cigarette Smoke Exposure on Acute Lung InjuryK23HL090833 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2008 to 2012
$761k
Clinical and Translational Science Award-K12KL2TR000088 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SHAMOON, HARRY · 2012 to 2013
$245k
Intranasal insulin for neuroprotection in elderly cardiac surgery patientsR03AG040673 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HSIEH, SHI-JUN JEAN · 2011 to 2012
$167k
NCATS NIH HHS 1 KL2 TR001071-01NCATS NIH HHS 1 TL1 TR001072-01NCATS NIH HHS 1 TL1TR001072-01NCATS NIH HHS 1 UL1 TR001073-01NCATS NIH HHS 8KL2TR0000088-05NCATS NIH HHS KL2 TR000088NCATS NIH HHS KL2 TR001071NCATS NIH HHS TL1 TR001072NCATS NIH HHS UL1 TR000004NCATS NIH HHS UL1 TR001073NCRR NIH HHS UL1 RR024131NHLBI NIH HHS HL090833NHLBI NIH HHS HL110969NHLBI NIH HHS HL51856NHLBI NIH HHS K23 HL090833NHLBI NIH HHS N01-HR-56165-56713NHLBI NIH HHS R01 HL110969NHLBI NIH HHS R37 HL051856NIA NIH HHS 1R03AG040673NIA NIH HHS R03 AG040673NIDA NIH HHS DA12393NIDA NIH HHS P30 DA012393PHS HHS HHSN268200536165CPHS HHS HHSN268200536176CPHS HHS HHSN268200536179C
6 · The paper itself

Abstract

objectivesCigarette smoke exposure has recently been found to be associated with increased susceptibility to trauma- and transfusion-associated acute respiratory distress syndrome. We sought to determine 1) the incidence of cigarette smoke exposure in a diverse multicenter sample of acute respiratory distress syndrome patients and 2) whether cigarette smoke exposure is associated with severity of lung injury and mortality in acute respiratory distress syndrome.

designAnalysis of the Albuterol for the Treatment of Acute Lung Injury and Omega Acute Respiratory Distress Syndrome Network studies.

settingAcute Respiratory Distress Syndrome Network hospitals. PATIENTS: Three hundred eighty-one patients with acute respiratory distress syndrome.

interventionsNone. MEASUREMENTS AND MAIN

results4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, a validated tobacco-specific marker, was measured in urine samples from subjects enrolled in two National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome Network randomized controlled trials. Urine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels were consistent with active smoking in 36% of acute respiratory distress syndrome patients and with passive smoking in 41% of nonsmokers (vs 20% and 40% in general population, respectively). Patients with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels in the active smoking range were younger and had a higher incidence of alcohol misuse, fewer comorbidities, lower severity of illness, and less septic shock at enrollment compared with patients with undetectable 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol levels. Despite this lower severity of illness, the severity of lung injury did not significantly differ based on biomarker-determined smoking status. Cigarette smoke exposure was not significantly associated with death after adjusting for differences in age, alcohol use, comorbidities, and severity of illness.

conclusionsIn this first multicenter study of biomarker-determined cigarette smoke exposure in acute respiratory distress syndrome patients, we found that active cigarette smoke exposure was significantly more prevalent among acute respiratory distress syndrome patients compared to population averages. Despite their younger age, better overall health, and lower severity of illness, smokers by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol had similar severity of lung injury as patients with undetectable 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. These findings suggest that active cigarette smoking may increase susceptibility to acute respiratory distress syndrome in younger, healthier patients.

Indexed as

Acute Lung InjuryAdultAgedAge FactorsAlcohol DrinkingAPACHEComorbidityFemaleHealth StatusHumansMaleMiddle AgedNitrosaminesPrevalencePyridinesRespiratory Distress Syndrome4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-olNitrosaminesPyridinesTobacco Smoke Pollution

Identifiers

PMID24942512
PMCPMC4134734
OpenAlexW2051662351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.