Evidence map›Paper›PMID 24942361›Full record

ArticleAlcoholism, clinical and experimental research2014

Social contexts of remission from DSM-5 alcohol use disorder in a high-risk sample.

Vivia V McCutcheon, John R Kramer, Howard J Edenberg, John I Nurnberger, Samuel Kuperman, Marc A Schuckit, Andrew C Heath, Kathleen K Bucholz

Abstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Vivia V McCutcheonDepartment of Psychiatry , Midwest Alcoholism Research Center, Washington University School of Medicine, St. Louis, Missouri.
John R Kramer
Howard J Edenberg
John I Nurnberger
Samuel Kuperman
Marc A Schuckit
Andrew C Heath
Kathleen K Bucholz

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7M
GENE-ENVIRONMENT INTERPLAY IN ALCOHOLISMK05AA017688 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 2008 to 2017
$1.9M
Predictors of Alcohol Recovery and Relapse Among Female Drunk DriversK01AA018146 · NIAAA · WASHINGTON UNIVERSITY · PI MCCUTCHEON, VIVIA V · 2009 to 2013
$594k
NIAAA NIH HHS AA017688NIAAA NIH HHS K01 AA018146NIAAA NIH HHS K01AA018146NIAAA NIH HHS K05 AA017688NIAAA NIH HHS U10 AA008401NIAAA NIH HHS U10AA008401
6 · The paper itself

Abstract

backgroundMeasures of social context, such as marriage and religious participation, are associated with remission from alcohol use disorders (AUDs) in population-based and treatment samples, but whether these associations hold among individuals at high familial risk for AUD is unknown. This study tests associations of measures of social context and treatment with different types of remission from DSM-5 AUD in a high-risk sample.

methodsSubjects were 686 relatives of probands (85.7% first-degree) who participated in a high-risk family study of alcohol dependence. All subjects met criteria for AUD at baseline and were re-interviewed 5 years later. Follow-up status was categorized as persistent AUD, high-risk drinking, remitted low-risk drinking, and abstinence. Social context measures were defined as stable or changing from baseline to follow-up, and their bivariate and multivariate associations with follow-up status were tested.

resultsAt follow-up, 62.8% of subjects had persistent AUD, 6.4% were high-risk drinkers, 22.2% were remitted low-risk drinkers, and 8.6% were abstinent. Birth of first child during the interval was the only measure of social context associated with remitted low-risk drinking and was significant for women only. Abstinent remission was characterized by being stably separated or divorced for women, new marriage for both sexes, experiencing low levels of family support and high levels of friend support, and receiving treatment. High-risk drinkers were more likely than individuals with persistent AUD to have a stable number of children and to have been recently unemployed.

conclusionsThe social contexts accompanying different types of remission in this high-risk sample resemble those found in population-based and clinical samples. Low-risk drinkers resemble natural remitters from population-based samples who change their drinking habits with life transitions. Abstainers resemble clinical samples in marital context, support from friends, and treatment. High-risk drinkers appear to continue to experience negative consequences of heavy drinking.

Indexed as

Remission InductionSocial SupportAdultAlcohol AbstinenceAlcoholismDiagnostic and Statistical Manual of Mental DisordersDrinking BehaviorEmploymentFemaleFollow-Up StudiesHumansMaleMarital StatusReligionRisk FactorsYoung AdultAlcohol Use DisorderRecoveryRemissionSocial ContextTreatment

Identifiers

PMID24942361
PMCPMC4107016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.