SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2014
Fibroblast growth factor 20 (FGF20) gene polymorphism and risk of Parkinson's disease: a meta-analysis.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- FGF family in health and disease.Molecular biomedicine · 2026Review
- FGF20 promotes spinal cord injury repair by inhibiting the formation of necrotic corpuscle P-MLKL/P-RIP1/P-RIP3 in neurons.Journal of cellular and molecular medicine · 2024Article
- Skeletal dysmorphology and mineralization defects in Fgf20 KO mice.Frontiers in endocrinology · 2024Article
- Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene.Molecular brain · 2018Article
- Genetic analysis of FGF20 in Chinese patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Systematic analysis of genetic variants in Han Chinese patients with sporadic Parkinson's disease.Scientific reports · 2016Article
- Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson's Disease.The Yale journal of biology and medicine · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibroblast growth factor 20 (FGF20) widely expressed in the substantia nigra is a neurotrophic factor and enhances the survival of midbrain dopaminergic neurons. Genetic association between variants in FGF20 gene (rs1721100) and PD has been reported, however, the results have been conflicting. A total of 3,463 PD patients and 4,606 controls from 5 case-control studies, which were identified by searching Web of Science, Embase and PubMed database up to March 2014, were collected for this meta-analysis. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model (GG versus CG+GG; OR = 1.15, 95 % CI 1.02-1.29, p = 0.02) but not under a dominant model (CG+GG versus CC; OR = 1.03, 95 % CI 0.93-1.13, p = 0.57). These findings suggest that rs1721100 GG genotype within FGF20 gene is a risk factor for PD. To our knowledge, this is the first meta-analysis to access to the association of FGF20 gene rs1721100 polymorphism with PD risk.
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