ArticleThe EMBO journal2014
The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase.
Article in The EMBO journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The AMIGa complex is at the crossroads of cytochrome c oxidase and ATP synthase biogenesis.EMBO reports · 2026Article
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- PHB3 Is Required for the Assembly and Activity of Mitochondrial ATP Synthase in Arabidopsis.International journal of molecular sciences · 2023Article
- The mitochondrial Hsp70 controls the assembly of the FNature communications · 2023Article
- Assembly-dependent translation of subunits 6 (Atp6) and 9 (Atp9) of ATP synthase in yeast mitochondria.Genetics · 2022Article
- Genetic Complementation of ATP Synthase Deficiency Due to Dysfunction of TMEM70 Assembly Factor in Rat.Biomedicines · 2022Article
- Applying Sodium Carbonate Extraction Mass Spectrometry to Investigate Defects in the Mitochondrial Respiratory Chain.Frontiers in cell and developmental biology · 2022Article
- Mitochondrial Structure and Bioenergetics in Normal and Disease Conditions.International journal of molecular sciences · 2021Review
- Transcriptomic and proteomic analyses of a new cytoplasmic male sterile line with a wild Gossypium bickii genetic background.BMC genomics · 2020Article
- MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes.Life science alliance · 2020Article
- Assembly of the membrane domain of ATP synthase in human mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Assembling the mitochondrial ATP synthase.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- The Peripheral Stalk of Rotary ATPases.Frontiers in physiology · 2018Review
- INA complex liaises the FNature communications · 2017Article
- Regulation of the HCellular and molecular life sciences : CMLS · 2017Review
- The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins.Nature communications · 2016Article
- Outer membrane protein functions as integrator of protein import and DNA inheritance in mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Article
- Mitochondrial heat shock protein (Hsp) 70 and Hsp10 cooperate in the formation of Hsp60 complexes.The Journal of biological chemistry · 2015Article
- Power(2): the power of yeast genetics applied to the powerhouse of the cell.Trends in endocrinology and metabolism: TEM · 2015Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial F1Fo-ATP synthase generates the bulk of cellular ATP. This molecular machine assembles from nuclear- and mitochondria-encoded subunits. Whereas chaperones for formation of the matrix-exposed hexameric F1-ATPase core domain have been identified, insight into how the nuclear-encoded F1-domain assembles with the membrane-embedded Fo-region is lacking. Here we identified the INA complex (INAC) in the inner membrane of mitochondria as an assembly factor involved in this process. Ina22 and Ina17 are INAC constituents that physically associate with the F1-module and peripheral stalk, but not with the assembled F1Fo-ATP synthase. Our analyses show that loss of Ina22 and Ina17 specifically impairs formation of the peripheral stalk that connects the catalytic F1-module to the membrane embedded Fo-domain. We conclude that INAC represents a matrix-exposed inner membrane protein complex that facilitates peripheral stalk assembly and thus promotes a key step in the biogenesis of mitochondrial F1Fo-ATP synthase.
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