ArticleJournal of pediatric hematology/oncology2015
Clinically meaningful interpretation of pediatric health-related quality of life in sickle cell disease.
Article in Journal of pediatric hematology/oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Health-related quality of life in hemoglobinopathies: A systematic review from a global perspective.Frontiers in pediatrics · 2022Pooled it
- HABIT Efficacy Trial Intervention Improves Elements of General and Disease-Specific Quality of Life in Youth With Sickle Cell Disease.Pediatric blood & cancer · 2025Trial
- Greater number of perceived barriers to hydroxyurea associated with poorer health-related quality of life in youth with sickle cell disease.Pediatric blood & cancer · 2019Trial
- Pain and opioid use after reversal of sickle cell disease following HLA-matched sibling haematopoietic stem cell transplant.British journal of haematology · 2019Trial
- HABIT, a Randomized Feasibility Trial to Increase Hydroxyurea Adherence, Suggests Improved Health-Related Quality of Life in Youths with Sickle Cell Disease.The Journal of pediatrics · 2018Trial
- Health-related quality of life in children with sickle cell anemia: impact of blood transfusion therapy.American journal of hematology · 2015Trial
- Coping Strategies and Social Support for Transition Readiness Among Youth With Sickle Cell Disease.JAMA network open · 2026Article
- Physical Therapy Surveillance in Children with Acute Lymphoblastic Leukemia: A Quality Improvement Initiative.Pediatric reports · 2026Article
- The Community Health Workers and Mobile Health for Emerging Adults Transitioning Sickle Cell Disease Care (COMETS) Trial: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2025Article
- Quality of Life and Psychological Functioning in Children with PFAPA Syndrome.Pediatric reports · 2025Article
- Pain, sleep, fatigue, and health-related quality of life in pediatric sickle cell disease: a serial multiple mediator analysis.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Inpatient Management of Pain Episodes in Children with Sickle Cell Disease: A Review.Children (Basel, Switzerland) · 2024Review
- ADaPTS "(AD)olescents (P)ath through (T)ransplant (S)ickle cell disease".Health and quality of life outcomes · 2022Article
- The influence of perceived racial bias and health-related stigma on quality of life among children with sickle cell disease.Ethnicity & health · 2022Article
- Health-Related Quality of Life Assessments by Children and Adolescents with Sickle Cell Disease and Their Parents in Portugal.Children (Basel, Switzerland) · 2022Article
- The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis.Journal of health economics and outcomes research · 2022Article
- Article
- Pain-Related Injustice Appraisals in Youth with Sickle Cell Disease: A Preliminary Investigation.Pain medicine (Malden, Mass.) · 2021Article
- Empirically Derived Profiles of Health-Related Quality of Life in Youth and Young Adults with Sickle Cell Disease.Journal of pediatric psychology · 2021Article
- Improvement in Health-Related Quality of Life After Community Acquired Pediatric Septic Shock.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Health-related quality of life (HRQL) measures provide information about disease assessment; however, health care providers may be reluctant to use HRQL assessments as scores can be difficult to interpret. We sought to identify levels for impaired pain-related HRQL in children with sickle cell disease (SCD). Children (n=251) completed the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales and PedsQL SCD Module in a multisite study. Using children's item scores on the Pain and Hurt and Pain Impact scales of the PedsQL SCD Module, High, Intermediate, and Low Functioning groups were created. We compared functioning groups with the Pain and Hurt and Pain Impact scale scores to determine levels representing high and low HRQL. These scores were compared with disease severity and the PedsQL Generic Core Scales. Scores of ≤60 on the PedsQL SCD Pain and Hurt and Pain Impact scales were associated with severe disease and met requirements for impaired functioning on the PedsQL Generic Core Scales. Scores of ≥81 on the Pain and Hurt and the Pain Impact scales can be considered consistent with good HRQL in those domains in SCD. Alternately, scores of ≤60 are cause for concern and suggest areas of HRQL impairment in SCD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.