ArticleBreast cancer research : BCR2014
Breast cancer risk assessment using genetic variants and risk factors in a Singapore Chinese population.
Article in Breast cancer research : BCR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of prediction models for risk of breast cancer.BMC cancer · 2025Pooled it
- Breast Cancer Risk From Modifiable and Non-Modifiable Risk Factors among Women in Southeast Asia: A Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2017Pooled it
- CHST9 rs1436904 genetic variant contributes to prognosis of triple-negative breast cancer.Scientific reports · 2017Trial
- Impact of a Panel of 88 Single Nucleotide Polymorphisms on the Risk of Breast Cancer in High-Risk Women: Results From Two Randomized Tamoxifen Prevention Trials.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Trial
- Knowledge-Guided Explainable Recommendation Tool for Cancer Risk Prediction Models Using Retrieval-Augmented Large Language Models: Development and Validation Study.JMIR medical informatics · 2026Article
- Potential Role of Zinc Finger 365Iranian journal of medical sciences · 2023Article
- Development of a Breast Cancer Risk Prediction Model Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Korean Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Development and validation of polygenic risk scores for prediction of breast cancer and breast cancer subtypes in Chinese women.BMC cancer · 2022Article
- Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women.JAMA network open · 2022Article
- A Scoping Review on the Status of Female Breast Cancer in Asia with a Special Focus on Nepal.Breast cancer (Dove Medical Press) · 2022Article
- Development and evaluation of the screening performance of a low-cost high-risk screening strategy for breast cancer.Cancer biology & medicine · 2021Article
- Breast Cancer Risk Prediction in Korean Women: Review and Perspectives on Personalized Breast Cancer Screening.Journal of breast cancer · 2020Review
- Clinical applications of polygenic breast cancer risk: a critical review and perspectives of an emerging field.Breast cancer research : BCR · 2020Review
- Genetic Testing to Guide Risk-Stratified Screens for Breast Cancer.Journal of personalized medicine · 2019Review
- The Variant at TGFBRAP1 but Not TGFBR2 Is Associated with Antituberculosis Drug-Induced Liver Injury.Evidence-based complementary and alternative medicine : eCAM · 2019Article
- Metformin Reshapes the Methylation Profile in Breast and Colorectal Cancer CellsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Risk, Prediction and Prevention of Hereditary Breast Cancer - Large-Scale Genomic Studies in Times of Big and Smart Data.Geburtshilfe und Frauenheilkunde · 2018Article
- Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese.Oncotarget · 2018Article
- Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry.Breast cancer research : BCR · 2016Article
- Developing a utility decision framework to evaluate predictive models in breast cancer risk estimation.Journal of medical imaging (Bellingham, Wash.) · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionGenetic variants for breast cancer risk identified in genome-wide association studies (GWAS) in Western populations require further testing in Asian populations. A risk assessment model incorporating both validated genetic variants and established risk factors may improve its performance in risk prediction of Asian women.
methodsA nested case-control study of female breast cancer (411 cases and 1,212 controls) within the Singapore Chinese Health Study was conducted to investigate the effects of 51 genetic variants identified in previous GWAS on breast cancer risk. The independent effect of these genetic variants was assessed by creating a summed genetic risk score (GRS) after adjustment for body mass index and the Gail model risk factors for breast cancer.
resultsThe GRS was an independent predictor of breast cancer risk in Chinese women. The multivariate-adjusted odds ratios (95% confidence intervals) of breast cancer for the second, third, and fourth quartiles of the GRS were 1.26 (0.90 to 1.76), 1.47 (1.06 to 2.04) and 1.75 (1.27 to 2.41) respectively (P for trend<0.001). In addition to established risk factors, the GRS improved the classification of 6.2% of women for their absolute risk of breast cancer in the next five years.
conclusionsGenetic variants on top of conventional risk factors can improve the risk prediction of breast cancer in Chinese women.
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