Evidence map›Paper›PMID 24941212›Full record

ArticlePediatric research2014

Efficacy of paracetamol on patent ductus arteriosus closure may be dose dependent: evidence from human and murine studies.

Afif El-Khuffash, Amish Jain, David Corcoran, Prakesh S Shah, Christopher W Hooper, Naoko Brown, Stanley D Poole, Elaine L Shelton, Ginger L Milne, Jeff Reese and 1 more

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04037514 (Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus), which is not on this map. Cited by 33 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04037514 phase3completednot on this mapstarted 2017, after this paper: background citation

Paracetamol Versus Ibuprofen in Premature Infants With Hemodynamically Significant Patent Ductus Arteriosus: a Randomized Clinical Trial

TypeinterventionalSponsorMáximo Vento TorresRan2017 to 2024Enrolled133ConditionsPatent Ductus Arteriosus After Premature BirthArmsParacetamol, Ibuprofen
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. A pilot randomised blinded placebo-controlled trial of paracetamol for later treatment of a patent ductus arteriosus.Journal of perinatology : official journal of the California Perinatal Association · 2019
    Trial
  7. Trial
  8. The clinical utility of paracetamol serum concentration monitoring for patent ductus arteriosus treatment in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Predictors of successful patent ductus arteriosus closure with acetaminophen in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Afif El-KhuffashDepartment of Pediatrics, The Rotunda Hospital, Dublin, Ireland.
Amish JainDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
David CorcoranDepartment of Pediatrics, The Rotunda Hospital, Dublin, Ireland.
Prakesh S ShahDepartment of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada.
Christopher W HooperDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Naoko BrownDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Stanley D PooleDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Elaine L SheltonDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Ginger L MilneDivision of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
Jeff ReeseDivision of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Patrick J McNamara1] Department of Neonatology, The Hospital for Sick Children, Toronto, Ontario, Canada [2] Department of Physiology and Experimental Medicine, Hospital for Sick Children, Toronto, Ontario, Canada.
Vanderbilt University Medical Center · USMount Sinai Hospital · CARotunda Hospital · IEHospital for Sick Children · CAVanderbilt University · US

Funding

Genes contributing to patent ductus arteriosus susceptibility in preterm newbornsR01HL109199 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CLYMAN, RONALD I · 2011 to 2014
$3.0M
Role of natriuretic peptides in the ductus arteriosusR01HL096967 · NHLBI · VANDERBILT UNIVERSITY · PI REESE, JOHN JEFFREY · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL096967NHLBI NIH HHS R01 HL109199
6 · The paper itself

Abstract

backgroundWe evaluated the clinical effectiveness of variable courses of paracetamol on patent ductus arteriosus (PDA) closure and examined its effect on the in vitro term and preterm murine ductus arteriosus (DA).

methodsNeonates received one of the following three paracetamol regimens: short course of oral paracetamol (SCOP), long course of oral paracetamol (LCOP), and intravenous paracetamol (IVP) for 2-6 d. Pressure myography was used to examine changes in vasomotor tone of the preterm and term mouse DA in response to paracetamol or indomethacin. Their effect on prostaglandin synthesis by DA explants was measured by mass spectroscopy.

resultsTwenty-one preterm infants were included. No changes in PDA hemodynamics were seen in SCOP infants (n = 5). The PDA became less significant and eventually closed in six LCOP infants (n = 7). PDA closure was achieved in eight IVP infants (n = 9). On pressure myograph, paracetamol induced a concentration-dependent constriction of the term mouse DA, up to 30% of baseline (P < 0.01), but required >1 µmol/l. Indomethacin induced greater DA constriction and suppression of prostaglandin synthesis (P < 0.05).

conclusionThe clinical efficacy of paracetamol on PDA closure may depend on the duration of treatment and the mode of administration. Paracetamol is less potent than indomethacin for constriction of the mouse DA in vitro.

Indexed as

AcetaminophenAdministration, IntravenousAdministration, OralAnimalsBlood PressureCyclooxygenase InhibitorsDose-Response Relationship, DrugDrug Administration ScheduleDuctus ArteriosusDuctus Arteriosus, PatentHumansIndomethacinInfant, NewbornLigationProstaglandin AntagonistsRetrospective StudiesAcetaminophenCyclooxygenase InhibitorsIndomethacinProstaglandin AntagonistsVasoconstrictor Agents

Identifiers

PMID24941212
PMCPMC4321957
OpenAlexW2022878856

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.