ArticleBiomedical optics express2014
In vivo imaging of nanoparticle delivery and tumor microvasculature with multimodal optical coherence tomography.
Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Modulated Doppler phase microscopy for dynamic imaging with subcellular resolution.Biomedical optics express · 2026Article
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Optical coherence tomography for noninvasive monitoring of drug delivery.Advanced drug delivery reviews · 2025Review
- NaYFMikrochimica acta · 2024Article
- Nanomaterials based on hollow gold nanospheres for cancer therapy.Regenerative biomaterials · 2024Review
- Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles.International journal of nanomedicine · 2022Review
- Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.Nano letters · 2021Article
- Gold nanomaterials for optical biosensing and bioimaging.Nanoscale advances · 2021Review
- X-ray-Based Techniques to Study the Nano-Bio Interface.ACS nano · 2021Article
- Quantification of Cellular Drug Biodistribution Addresses Challenges in EvaluatingAdvanced therapeutics · 2021Article
- Investigation of GdJournal of fluorescence · 2021Article
- Article
- Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents.Translational vision science & technology · 2019Article
- Light-responsive nanomedicine for biophotonic imaging and targeted therapy.Advanced drug delivery reviews · 2019Review
- In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.Scientific reports · 2017Article
- Complex effects of tumor microenvironment on the tumor disposition of carrier-mediated agents.Nanomedicine (London, England) · 2017Review
- Near Infrared Fluorescence Imaging in Nano-Therapeutics and Photo-Thermal Evaluation.International journal of molecular sciences · 2017Review
- Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography.Biomedical optics express · 2016Article
- High-resolution contrast-enhanced optical coherence tomography in mice retinae.Journal of biomedical optics · 2016Article
- Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Current imaging techniques capable of tracking nanoparticles in vivo supply either a large field of view or cellular resolution, but not both. Here, we demonstrate a multimodality imaging platform of optical coherence tomography (OCT) techniques for high resolution, wide field of view in vivo imaging of nanoparticles. This platform includes the first in vivo images of nanoparticle pharmacokinetics acquired with photothermal OCT (PTOCT), along with overlaying images of microvascular and tissue morphology. Gold nanorods (51.8 ± 8.1 nm by 15.2 ± 3.3 nm) were intravenously injected into mice, and their accumulation into mammary tumors was non-invasively imaged in vivo in three dimensions over 24 hours using PTOCT. Spatial frequency analysis of PTOCT images indicated that gold nanorods reached peak distribution throughout the tumors by 16 hours, and remained well-dispersed up to 24 hours post-injection. In contrast, the overall accumulation of gold nanorods within the tumors peaked around 16 hours post-injection. The accumulation of gold nanorods within the tumors was validated post-mortem with multiphoton microscopy. This shows the utility of PTOCT as part of a powerful multimodality imaging platform for the development of nanomedicines and drug delivery technologies.
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Registered trials
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