Evidence map›Paper›PMID 24940395›Full record

ArticleExperimental and therapeutic medicine2014

A retrospective study of cytomegalovirus pneumonia in renal transplant patients.

Biao Dong, Yuantao Wang, Gang Wang, Weigang Wang, Honglan Zhou, Yaowen Fu

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02973464 (The Strategy in the Prevention of Renal Post-transplant Cytomegalovirus Infection Among Chinese Population), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02973464 unknown statusnot on this mapstarted 2016, after this paper: background citation

The Strategy in the Prevention of Renal Post-transplant Cytomegalovirus Infection Among Chinese Population

TypeobservationalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2016 to 2019Enrolled450ConditionsRenal Transplant RecipientsArmsValganciclovir, Ganciclovir
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Biao DongDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Yuantao WangDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Gang WangDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Weigang WangDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Honglan ZhouDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Yaowen FuDepartment of Urology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Jilin University · CNFirst Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to investigate an optimal prophylaxis of cytomegalovirus (CMV) pneumonia in renal transplant recipients. A total of 83 kidney transplant recipients who had been diagnosed with CMV pneumonia between January 2008 and December 2011 were enrolled in the study. Patients were assigned to a standard or improved group based on the prophylaxis administered. The retrospective study was undertaken to compare the incidence of CMV pneumonia, cure rate or recovery rate and mortality between the two groups. The results indicated that a longer duration of prophylaxis with oral ganciclovir effectively reduced the risk of CMV pneumonia in kidney transplant recipients. Treatments, including early withdrawal of immunosuppressants, regular use of glucocorticosteroids and careful supportive therapy, were beneficial in controlling CMV pneumonia. Furthermore, antibody induction therapy may not increase the risk of CMV pneumonia in kidney recipients administered proper prophylaxis [3-month course of oral ganciclovir and trimethoprim-sulfamethoxazole (SMZ-TMP)]. Therefore, the present study demonstrated that a longer duration of prophylaxis with oral ganciclovir, withdrawal of immunosuppressants and regular use of glucocorticosteroids may be improved treatments for CMV pneumonia.

Indexed as

cytomegalovirus pneumoniaglucocorticosteroidimmunosuppressantsinduction therapykidney transplantation

Identifiers

PMID24940395
PMCPMC3991547
OpenAlexW1972058043

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.