ArticleAfrican health sciences2013
In vivo hypoglycemic effect of methanolic fruit extract of Momordica charantia L.
Article in African health sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- A novel hydrogel loaded with plant exosomes and stem cell exosomes as a new strategy for treating diabetic wounds.Materials today. Bio · 2025Article
- Bitter melon extract suppresses metastatic breast cancer cells (MCF-7 cells) growth possibly by hindering glucose uptake.microPublication biology · 2023Article
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- Mormodica charantia L. fruit and Genistein ameliorates type 2 diabetes in rats by preventing lipid accumulation, insulin resistance and enhancing beta cell function.Journal of diabetes and metabolic disorders · 2020Article
- Indian Traditional medicinal plants as a source of potent Anti-diabetic agents: A Review.Journal of diabetes and metabolic disorders · 2020Review
- Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review.Oxidative medicine and cellular longevity · 2020Review
- Effect of Myristica fragrans extract on total body composition in cafeteria diet induced obese rats.Bioinformation · 2019Article
- GLP-I secretion in healthy and diabetic Wistar rats in response to aqueous extract of Momordica charantia.BMC complementary and alternative medicine · 2018Article
- Bitter melon: a panacea for inflammation and cancer.Chinese journal of natural medicines · 2016Review
- Evaluation of Phenolic Content Variability along with Antioxidant, Antimicrobial, and Cytotoxic Potential of Selected Traditional Medicinal Plants from India.Frontiers in plant science · 2016Article
- The effect of Momordica charantia intake on the estrogen receptors ESRα/ESRβ gene levels and apoptosis on uterine tissue in ovariectomy rats.Molecular biology reports · 2015Article
- Infections and non-communicable diseases that just refuse to go away.African health sciences · 2013Article
- Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects.The review of diabetic studies : RDSReview
- The therapeutic potential of Wild Bitter Melon to ameliorate muscle atrophy in a murine model.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMomordica charantia L. is a medicinal plant commonly used in the management of diabetes mellitus.
objectivesWe investigated the blood glucose lowering effect of the methanolic fruit extract of the Ugandan variety of M. charantia L. in alloxan-induced diabetic albino rats.
methods500g of M. charantia powder were macerated in methanol and the extract administered to two groups of alloxan-induced diabetic rats. The first group received 125mg/kg, the second 375mg/kg and a third group 7mg/kg of metformin. A fourth group received 1ml normal saline. Fasting blood glucose (FBG) levels were measured at 0.5,1,2,3,5,8 and 12 hours and compared using one-way ANOVA.
resultsThere was an initial rise in FBG for 1 hour after administration of extracts followed by steep reductions. Significant reduction in FBG occurred at 2 hours for 125mg/kg of extract (-3.2%, 313±25.9 to 303±25.0mg/dL, p = 0.049), 375mg/kg of extract (-3.9%, 356±19.7 to 342±20.3mg/dL, p = 0.001), and metformin (-2.6%, 344±21.7 to 335±21.1mg/dL, p = 0.003) when compared to normal saline. The maximum percentage reduction in FBG by both extracts occurred between 3 and 12 hours post dose.
conclusionsThe methanolic fruit extract of M. charantia exhibits dose dependent hypoglycaemic activity in vivo.
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