ReviewOchsner journal2014
Availability and utilization of opioids for pain management: global issues.
Review in Ochsner journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.The Cochrane database of systematic reviews · 2022Pooled it
- Perceptions and experiences of laws and regulations governing access to opioids in South, Southeast, East and Central Asia: A systematic review, critical interpretative synthesis and development of a conceptual framework.Palliative medicine · 2021Pooled it
- Challenges on the provision of palliative care for patients with cancer in low- and middle-income countries: a systematic review of reviews.BMC palliative care · 2020Pooled it
- A Systematic Review of Laboratory Evidence for the Abuse Potential of Tramadol in Humans.Frontiers in psychiatry · 2019Pooled it
- Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care.The Cochrane database of systematic reviews · 2018Pooled it
- Small-Molecule Drugs Approved by the FDA in 2025.Molecules (Basel, Switzerland) · 2026Review
- Non-Medical Opioid Use in Ethiopia: An Exploratory Descriptive Study.Ethiopian journal of health sciences · 2026Article
- Anvisa authorization for electronic prescriptions of controlled substances: implications for equity in access to pain management in Brazil.Cadernos de saude publica · 2026Article
- Observational
- The Synergistic Effect of Heat Therapy and Electroacupuncture Treatment in Inflammatory Pain Mouse Models.Brain sciences · 2025Article
- Global and regional burden of four drug use disorders in the elderly, 1990 to 2021: an analysis of the global burden of disease study.BMC geriatrics · 2025Article
- Evaluating pain outcomes in Chinese ophthalmology patients using the APS-POQ-R-C: a Rasch analysis.Frontiers in psychology · 2025Article
- Article
- Trends in pain undertreatment among lung cancer patients at the EOL: Analysis of urban city medical insurance data in China.Thoracic cancer · 2024Article
- Mind-Body Training: A Plausible Strategy against Osteomuscular Chronic Pain-A Systematic Review with Meta-Analysis.Journal of personalized medicine · 2024Review
- Antinociceptive and anti-inflammatory actions of curcumin and nano curcumin: a comparative study.Research in pharmaceutical sciences · 2023Article
- Availability and Use of Essential Opioid Analgesics in Sub-Saharan Africa: A Scoping Review Protocol.International journal of surgery protocols · 2023Article
- Post-operative pain and associated factors after cesarean section at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia: A cross-sectional study.Annals of medicine and surgery (2012) · 2022Article
- Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication.Journal of immunology research · 2022Article
- Morphine promotes angiogenesis by activating PI3K/Akt/HIF-1α pathway and upregulating VEGF in hepatocellular carcinoma.Journal of gastrointestinal oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPain can significantly influence an individual's health status and can have serious negative consequences: poor nutrition, decreased appetite, abnormal sleep patterns, fatigue, and impairment of daily living activities. Pain can cause psychological impairment and decrease healing and recovery from injuries and illness. A hallmark of many chronic conditions, pain affects more patients' lives than diabetes mellitus, heart disease, and cancer combined. However, many chronic sufferers do not have access to effective pain management for a variety of reasons, including limited access, restrictions, and personal and cultural biases.
methodsThis review summarizes issues of access, distribution, and cultural bias with regard to opioid agents and seeks to clarify the challenges related to opioid delivery. The considerable negative physical and mental consequences of chronic pain are discussed for the general and palliative care population.
resultsOpioids are an effective treatment for various intractable painful conditions, but problems in global opioid access for safe and rational use in pain management contribute to unnecessary suffering. These problems persist despite increased understanding in recent years of the pathophysiology of pain.
conclusionsComprehensive guidelines for goal-directed and patient-friendly chronic opiate therapy will potentially enhance the outlook for future chronic pain management. The improvement of pain education in undergraduate and postgraduate training will benefit patients and clinicians. The promise of new medications, along with the utilization of multimodal approaches, has the potential to provide effective pain relief to future generations of sufferers.
Indexed as
Identifiers
24940131PMC4052588What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.