ArticleGenetics2014
Estimating tempo and mode of Y chromosome turnover: explaining Y chromosome loss with the fragile Y hypothesis.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 68 citations in OpenAlex.
- Chromosome-Level Reference Genome of an Endemic, Endangered Long-Armed Scarab (Ecology and evolution · 2026Article
- Identification of sex chromosome, sex-biased gene expression and dosage compensation in the pygmy mole cricket Xya riparia (Orthoptera: Tridactyloidea).BMC genomics · 2026Article
- Evolutionary Dynamics of Dosage Compensation and Sex-biased Gene Expression in Morabine Grasshopper Vandiemenella viatica.Genome biology and evolution · 2026Article
- The tortured past of young polymorphic sex chromosomes revealed through multiplebioRxiv : the preprint server for biology · 2026Article
- The Tree of Sex consortium: a global initiative for studying the evolution of reproduction in eukaryotes.Journal of evolutionary biology · 2025Article
- Sex and neo-sex chromosome evolution in beetles.PLoS genetics · 2024Article
- Drift drives the evolution of chromosome number II: The impact of range size on genome evolution in Carnivora.The Journal of heredity · 2024Article
- Evidence for feminized genetic males in a flea beetle using newly identified X-linked markers.Ecology and evolution · 2024Article
- Drift drives the evolution of chromosome number I: The impact of trait transitions on genome evolution in Coleoptera.The Journal of heredity · 2024Article
- scRNA-seq Reveals Novel Genetic Pathways and Sex Chromosome Regulation in Tribolium Spermatogenesis.Genome biology and evolution · 2024Article
- Article
- Y-Linked Copy Number Polymorphism of Target of Rapamycin Is Associated with Sexual Size Dimorphism in Seed Beetles.Molecular biology and evolution · 2023Article
- Return of the forgotten hero: the role of Y chromosome-encoded Zfy in male reproduction.Molecular human reproduction · 2023Article
- Giant Sex Chromosomes inInsects · 2023Article
- Article
- X chromosomes show relaxed selection and complete somatic dosage compensation across Timema stick insect species.Journal of evolutionary biology · 2022Article
- Why not Y naught.Heredity · 2022Review
- Fragile, unfaithful and persistent Ys-on how meiosis can shape sex chromosome evolution.Heredity · 2022Article
- Detection of sex in adults and larvae of Leptinotarsa decemlineata on principle of copy number variation.Scientific reports · 2022Article
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Chromosomal sex determination is phylogenetically widespread, having arisen independently in many lineages. Decades of theoretical work provide predictions about sex chromosome differentiation that are well supported by observations in both XY and ZW systems. However, the phylogenetic scope of previous work gives us a limited understanding of the pace of sex chromosome gain and loss and why Y or W chromosomes are more often lost in some lineages than others, creating XO or ZO systems. To gain phylogenetic breadth we therefore assembled a database of 4724 beetle species' karyotypes and found substantial variation in sex chromosome systems. We used the data to estimate rates of Y chromosome gain and loss across a phylogeny of 1126 taxa estimated from seven genes. Contrary to our initial expectations, we find that highly degenerated Y chromosomes of many members of the suborder Polyphaga are rarely lost, and that cases of Y chromosome loss are strongly associated with chiasmatic segregation during male meiosis. We propose the "fragile Y" hypothesis, that recurrent selection to reduce recombination between the X and Y chromosome leads to the evolution of a small pseudoautosomal region (PAR), which, in taxa that require XY chiasmata for proper segregation during meiosis, increases the probability of aneuploid gamete production, with Y chromosome loss. This hypothesis predicts that taxa that evolve achiasmatic segregation during male meiosis will rarely lose the Y chromosome. We discuss data from mammals, which are consistent with our prediction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.