ArticleJournal of lipid research2014
Characterization of acyl chain position in unsaturated phosphatidylcholines using differential mobility-mass spectrometry.
Article in Journal of lipid research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 114 citations in OpenAlex.
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- Temperature adaptation of yeast phospholipid molecular species at the acyl chain positional level.FEBS letters · 2025Article
- Quantitative Lipidomics of Biological Samples Using Supercritical Fluid Chromatography Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Identification and Imaging of Prostaglandin Isomers Utilizing MSJournal of the American Society for Mass Spectrometry · 2023Article
- Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers.Frontiers in molecular biosciences · 2023Review
- Quantitative determination of sn-positional phospholipid isomers in MSAnalytical and bioanalytical chemistry · 2022Article
- Voltage-Controlled Divergent Cascade of Electrochemical Reactions for Characterization of Lipids at Multiple Isomer Levels Using Mass Spectrometry.Analytical chemistry · 2022Article
- Hatching egg polyunsaturated fatty acids and the broiler chick.Journal of animal science and biotechnology · 2022Review
- Characterization of lipid carbon-carbon double-bond isomerism via ion mobility-mass spectrometry (IMS-MS) combined with cuprous ion-induced fragmentation.International journal of mass spectrometry · 2022Article
- Cryogenic infrared spectroscopy provides mechanistic insight into the fragmentation of phospholipid silver adducts.Analytical and bioanalytical chemistry · 2022Article
- Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy.Nature communications · 2021Article
- Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures.Journal of lipid research · 2020Article
- Separating chiral isomers of amphetamine and methamphetamine using chemical derivatization and differential mobility spectrometry.Analytical science advances · 2020Article
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- Large-scale lipid analysis with C=C location and sn-position isomer resolving power.Nature communications · 2020Article
- Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry.Journal of lipid research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycerophospholipids (GPs) that differ in the relative position of the two fatty acyl chains on the glycerol backbone (i.e., sn-positional isomers) can have distinct physicochemical properties. The unambiguous assignment of acyl chain position to an individual GP represents a significant analytical challenge. Here we describe a workflow where phosphatidylcholines (PCs) are subjected to ESI for characterization by a combination of differential mobility spectrometry and MS (DMS-MS). When infused as a mixture, ions formed from silver adduction of each phospholipid isomer {e.g., [PC (16:0/18:1) + Ag](+) and [PC (18:1/16:0) + Ag](+)} are transmitted through the DMS device at discrete compensation voltages. Varying their relative amounts allows facile and unambiguous assignment of the sn-positions of the fatty acyl chains for each isomer. Integration of the well-resolved ion populations provides a rapid method (< 3 min) for relative quantification of these lipid isomers. The DMS-MS results show excellent agreement with established, but time-consuming, enzymatic approaches and also provide superior accuracy to methods that rely on MS alone. The advantages of this DMS-MS method in identification and quantification of GP isomer populations is demonstrated by direct analysis of complex biological extracts without any prior fractionation.
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