ArticleNucleic acids research2014
Two cationic porphyrin isomers showing different multimeric G-quadruplex recognition specificity against monomeric G-quadruplexes.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance.Journal of pharmaceutical analysis · 2023Article
- Towards Computational Modeling of Ligand Binding to the ILPR G-Quadruplex.Molecules (Basel, Switzerland) · 2023Article
- The Binding Pocket at the Interface of Multimeric Telomere G-quadruplexes: Myth or Reality?Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Quadruplex Ligands in Cancer Therapy.Cancers · 2021Review
- BMPQ-1 binds selectively to (3+1) hybrid topologies in human telomeric G-quadruplex multimers.Nucleic acids research · 2020Article
- Why do G-quadruplexes dimerize through the 5'-ends? Driving forces for G4 DNA dimerization examined in atomic detail.PLoS computational biology · 2019Article
- Structure and Function of Multimeric G-Quadruplexes.Molecules (Basel, Switzerland) · 2019Review
- Importance of Chiral Recognition in Designing Metal-Free Ligands for G-Quadruplex DNA.Molecules (Basel, Switzerland) · 2019Article
- Cationic porphyrins with large side arm substituents as resonance light scattering ratiometric probes for specific recognition of nucleic acid G-quadruplexes.Nucleic acids research · 2019Article
- Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy.Molecules (Basel, Switzerland) · 2019Review
- Solution structures of multiple G-quadruplex complexes induced by a platinum(II)-based tripod reveal dynamic binding.Nature communications · 2018Article
- A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder.RSC advances · 2018Article
- DNA mimics of red fluorescent proteins (RFP) based on G-quadruplex-confined synthetic RFP chromophores.Nucleic acids research · 2017Article
- Interaction between G-Quadruplex and Zinc Cationic Porphyrin: The Role of the Axial Water.Scientific reports · 2017Article
- Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy.Nucleic acids research · 2017Article
- Dinickel-Salphen Complexes as Binders of Human Telomeric Dimeric G-Quadruplexes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole.Nucleic acids research · 2017Article
- Combining a Ru(II) "Building Block" and Rapid Screening Approach to Identify DNA Structure-Selective "Light Switch" Compounds.ACS combinatorial science · 2017Article
- RNA G-quadruplexes and their potential regulatory roles in translation.Translation (Austin, Tex.) · 2016Review
- Divalent cations and molecular crowding buffers stabilize G-triplex at physiologically relevant temperatures.Scientific reports · 2015Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ligands that can interact specifically with telomeric multimeric G-quadruplexes could be developed as promising anticancer drugs with few side effects related to other G-quadruplex-forming regions. In this paper, a new cationic porphyrin derivative, m-TMPipEOPP, was synthesized and characterized. Its multimeric G-quadruplex recognition specificity under molecular crowding conditions was compared to its isomer p-TMPipEOPP. The slight structural difference accounts for different multimeric G-quadruplex recognition specificity for the two isomers. p-TMPipEOPP can barely discriminate between multimeric and monomeric G-quadruplexes. By contrast, m-TMPipEOPP can bind with multimeric but not with monomeric G-quadruplexes. p-TMPipEOPP might bind to multimeric G-quadruplexes by two modes: sandwich-like end-stacking mode and pocket-dependent intercalative mode. Increasing the pocket size between adjacent two G-quadruplex units is beneficial for the latter mode. m-TMPipEOPP might bind to multimeric G-quadruplexes by a side binding mode, which confers m-TMPipEOPP with higher multimeric G-quadruplex recognition specificity compared to p-TMPipEOPP. m-TMPipEOPP increases the stability of multimeric G-quadruplex under both dilute and molecular crowding conditions but its G-quadruplex-stabilizing ability is a little weaker than p-TMPipEOPP. These results provide important information for the design of highly specific multimeric G-quadruplex ligands. Another interesting finding is that pocket size is an important factor in determining the stability of multimeric G-quadruplexes.
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