ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2014
mRNA-Seq and microRNA-Seq whole-transcriptome analyses of rhesus monkey embryonic stem cell neural differentiation revealed the potential regulators of rosette neural stem cells.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- MiRNA Dysregulation in Brain Injury: AnCurrent neuropharmacology · 2025Article
- Generation of a human haploid neural stem cell line for genome-wide genetic screening.World journal of stem cells · 2023Article
- The Impaired Neurodevelopment of Human Neural Rosettes in HSV-1-Infected Early Brain Organoids.Cells · 2022Article
- Somatic retrotransposition in the developing rhesus macaque brain.Genome research · 2022Article
- Loss of ZC4H2 and RNF220 Inhibits Neural Stem Cell Proliferation and Promotes Neuronal Differentiation.Cells · 2020Article
- Cell-Type Transcriptomes of the Multicellular Green AlgaG3 (Bethesda, Md.) · 2018Article
- Identification of Altered Developmental Pathways in Human Juvenile HD iPSC With 71Q and 109Q Using Transcriptome Profiling.Frontiers in cellular neuroscience · 2018Article
- miR‑146b‑5p promotes the neural conversion of pluripotent stem cells by targeting Smad4.International journal of molecular medicine · 2017Article
- Reconstruction and applications of consensus yeast metabolic network based on RNA sequencing.FEBS open bio · 2016Article
- MicroRNA-765 regulates neural stem cell proliferation and differentiation by modulating Hes1 expression.American journal of translational research · 2016Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rosette neural stem cells (R-NSCs) represent early stage of neural development and possess full neural differentiation and regionalization capacities. R-NSCs are considered as stem cells of neural lineage and have important implications in the study of neurogenesis and cell replacement therapy. However, the molecules regulating their functional properties remain largely unknown. Rhesus monkey is an ideal model to study human neural degenerative diseases and plays intermediate translational roles as therapeutic strategies evolved from rodent systems to human clinical applications. In this study, we derived R-NSCs from rhesus monkey embryonic stem cells (ESCs) and systematically investigated the unique expressions of mRNAs, microRNAs (miRNAs), and signalling pathways by genome-wide comparison of the mRNA and miRNA profilings of ESCs, R-NSCs at early (R-NSCP1) and late (R-NSCP6) passages, and neural progenitor cells. Apart from the R-NSCP1-specific protein-coding genes and miRNAs, we identified several pathways including Hedgehog and Wnt highly activated in R-NSCP1. The possible regulatory interactions among the miRNAs, protein-coding genes, and signalling pathways were proposed. Besides, many genes with alternative splicing switch were identified at R-NSCP1. These data provided valuable resource to understand the regulation of early neurogenesis and to better manipulate the R-NSCs for cell replacement therapy.
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